PONE-D-21-18930

A preoperative predictive study of advantages of airway changes after maxillomandibular advancement surgery using computational fluid dynamics analysis

PLOS ONE

Dear Dr. Shinozuka,

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Reviewers' comments:

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Comments to the Author

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The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: The manuscript is well written, however minor corrections are needed to improve the quality.

Introduction

line 44, It has been shown that obstructive sleep apneas are also correlated with different comoribidities compared to the classic cardiovascular ones. In fact, a correlation has recently been reported between OSAS and nasal disorders both sensory with altered smell and inflammation the alteration of different demonstrable biomarkers such as oxygen free radicals, cell free DNA or lipid peroxidation. please cite the paper DOI:10.1007/s00405-020-06316-w and DOI:10.3390/jcm10020277

Methods

the methods used correct and well structured.

The results are consistent with the methods set out.

Figures are really interesting, representing well what the results presuppose.

Discussion correct and inherent.

Reviewer #2: Interesting paper, only few suggestions to improve the structure and make it more fascinable:

Introduction, after line 49:

- In the case of a retrolingual obstruction it is not always necessary to intervene through mandibular advancement, especially if there is a lymphatic lingual base hypertrophy or a primary epiglottis that can be modeled through a supraglottoplasty. please cite DOI:10.1002/rcs.2106

- A comparative stress test demonstrated excellent distribution of palatal vector forces after barbed surgery, reallocating and shaping the soft tissues in order to avoid collapsing of the walls. please cite DOI:10.1007/s00405-020-05883-2

Methods and Results really fascinating as the figures.

Good job!

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Reviewer #1: No

Reviewer #2: No

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A preoperative predictive study of advantages of airway changes after maxillomandibular advancement surgery using computational fluid dynamics analysis

PONE-D-21-18930R1

Dear Dr. Shinozuka,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

This is a very interesting study about airway changes after maxillomandibular advancement surgery using computational fluid dynamics analysis in OSA patients. The stusy is innovative and well conducted. Authors well improved the manuscript according to the comments of reviewers.

In my opinion it is suitable for the pubblication on PLOS-ONE.

Reviewers' comments:

-