PONE-D-21-10465

EEG p-adic quantum potential accurately identifies depression, schizophrenia and cognitive decline

PLOS ONE

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PLOS ONE

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Additional Editor Comments (if provided):

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: I Don't Know

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: No

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The biological information transduction behaves quantum-like, therefore, it is well described and understood according to the principle and operations of quantum mechanism. The manuscript is a marvelous application of the research achievement of trying to understand the biological information processing in terms of quantum mechanism. I believe the success of this application in diagnosis of psychiatric patients should be widely open. Further, the success of discrimination between various types of such diseases is especially surprising, which can be used in research development to understand the detailed mechanism of the origin and development of such various diseases.

Minor concern is: “Does the control contain not only healthy people but also other brain patients than the psychiatric patients reported in this manuscript, such as brain cancer, migraine, and so on?” This is important at the practical application for the medical diagnosis of each individual patient. At least the authors should mention about this at the discussion section.

English is awkward at several places. Corrections by a native speaker should help the improvement.

Reviewer #2: The paper introduces new a quantum potential mean and variability score (qpmvs), to identify neuropsychiatric and neurocognitive disorders with high accuracy, based on EEG recordings. It is fascinating, highly interdisciplinary, paper involving quantum physics, neurophysiology, among other areas. My report is dedicated only to the physics/mahematics of the qpmvs. In my view, the description of the underlying physical model requires serious improvements. I suggest including an appendix explaining the model and its numerical implementation. Please see the attached file.

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Reviewer #1: Yes: Ichiro Yamato

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PONE-D-21-10465_Report.pdf

EEG p-adic quantum potential accurately identifies depression, schizophrenia and cognitive decline

PONE-D-21-10465R1

Dear Dr. Benninger,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Giuseppe Vitiello

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Dear Dr. Felix Benninger,

it is a pleasure to communicate you that your paper has been accepted to be published on PLOS ONE.

Best regards

Giuseppe Vitiello

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: (No Response)

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: (No Response)

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: (No Response)

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: (No Response)

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: You addressed adequately to my concern. Thank you for your providing a nice diagnostic analysis method for psychological diseases. I hope you continue investigation further on the control patients to discriminate clearly the psychological diseases from other kinds of brain diseases. Looking forward to reading your further reports.

I suggest you to be more careful about simple English errors such as: Introduction section, 2nd paragraph, Baring -> Bearing; Method section, 2-adic part, 4. normalized -> Normalized; time step, t, normalized -> time step, t, were normalized; and several others; Fig.1 legend, 3rd line, Qmet,group the for comparison -> Qmet,group for comparison.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Ichiro Yamato