Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients

Juan Alonso Leon-Abarca; Arianna Portmann-Baracco; Mayte Bryce-Alberti; Carlos Ruiz-Sánchez; Roberto Alfonso Accinelli; Jorge Soliz; Gustavo Francisco Gonzales

doi:10.1371/journal.pone.0255144

Peer Review History

Original SubmissionDecember 9, 2020
17 May 2021 Decision Letter - Chiara Lazzeri, Editor PONE-D-20-38743 Diabetes increases the risk of COVID-19 in an altitude dependent manner: an analysis of 1,280,806 Mexican patients PLOS ONE Dear Dr. Accinelli, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. The present investigation addresses an interesting topic, the relationship between DM and altitude in COVID disease. We suggest to shorten the discussion section and to focus on this peculiar relationship, trying to elucidate potential mechanisms. Please submit your revised manuscript by Jul 01 2021 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. 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The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf 2. In your Methods section, please provide additional information about the data collection methods and the demographic details of your participants. Please ensure you have provided sufficient details to replicate the analyses such as: a) the dates the medical records were originally collected, b) the dates on which you accessed the databases c) a table of relevant demographic details, d) the institutions that participants were treated at originally. 3. Please amend your list of authors on the manuscript to ensure that each author is linked to an affiliation. 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Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes ****** 4. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes ****** 5. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: p3 ln 92 - constraints of this study = better suited for the discussion section p3 ln 100 - ethics etc - name of the committee that Ok-ed the study and date of approval Discussion - Less on DM and Covid-19 (which is widely known) - focus on attitude and Covid-19 (which is less well known) ****** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. 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Revision 1
6 Jul 2021 Author Response 1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf a) The style has been corrected 2. In your Methods section, please provide additional information about the data collection methods and the demographic details of your participants. Please ensure you have provided sufficient details to replicate the analyses such as: a) the dates the medical records were originally collected, i. Data was accesed at Sept 9th 2020. As the Mexican government releases their databases to the public domain with a 24 hour delay, the available registers dated until Sept 8th 2020. b) the dates on which you accessed the databases i. Now specified in methods: Data was accesed at Sept 9th 2020. c) a table of relevant demographic details i. Now available as “Table 1” d) the institutions that participants were treated at originally. i. As the list of healthcare institutions is extensive due to the nature of the database (nation-wide), we specifify in “Methods” that we included all patients treated along the 475 USMERs (Monitoring Units of Viral Respiratory Infections, acronym in spanish) 3. Please amend your list of authors on the manuscript to ensure that each author is linked to an affiliation. Authors’ affiliations should reflect the institution where the work was done (if authors moved subsequently, you can also list the new affiliation stating “current affiliation:….” as necessary). a) The style has been corrected 4. Please include a copy of Tables 1 and 2 which you refer to in your text on page 4 and 5. a) Tables 1 and 2 are now attached to the manuscript 5. Reviewer #1: p3 ln 92 - constraints of this study = better suited for the discussion section a) Constraints were added to the discussion section. 6. p3 ln 100 - ethics etc - name of the committee that Ok-ed the study and date of approval a) We wrote: “approval from an institutional ethics committee” b) Now it says: “The study received approval from Universidad Peruana Cayetano Heredia’s ethics committee with registration number SIDISI 202908. “ 7. Discussion - Less on DM and Covid-19 (which is widely known) - focus on attitude and Covid-19 (which is less well known) a) The discussion now focuses on the possible pathophysiology related to our findings. Attachments Attachment Submitted filename: Response to reviewers.docx https://doi.org/10.1371/journal.pone.0255144.r002
12 Jul 2021 Decision Letter - Chiara Lazzeri, Editor Diabetes increases the risk of COVID-19 in an altitude dependent manner: an analysis of 1,280,806 Mexican patients PONE-D-20-38743R1 Dear Dr. Accinelli, We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements. Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication. An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org. If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. Kind regards, Chiara Lazzeri Academic Editor PLOS ONE Additional Editor Comments (optional): Reviewers' comments: https://doi.org/10.1371/journal.pone.0255144.r003
Formally Accepted
21 Jul 2021 Acceptance Letter - Chiara Lazzeri, Editor PONE-D-20-38743R1 Diabetes increases the risk of COVID-19 in an altitude dependent manner: an analysis of 1,280,806 Mexican patients. Dear Dr. Accinelli: I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org. If we can help with anything else, please email us at plosone@plos.org. Thank you for submitting your work to PLOS ONE and supporting open access. Kind regards, PLOS ONE Editorial Office Staff on behalf of Dr. Chiara Lazzeri Academic Editor PLOS ONE https://doi.org/10.1371/journal.pone.0255144.r004

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