PONE-D-21-12701

Incidence, Predictors, and Outcomes of DAPT Non-compliance in Planned vs. Ad Hoc PCI in Chronic Coronary Syndrome

PLOS ONE

Dear Dr. Malik,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

The reviewers generally found the manuscript and revisions acceptable, but still have considerable questions regarding multiple parts of the manuscript. Please pay careful attention these issues in an itemized fashion, and we look forward to your revisions. 

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PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Dear Authors,

thank you for your valuable contribution and congratulation on your work in this not well-defined scenario. The paper is well-written considering English fluency, and the study is well-conducted about major biases.

I have some comments:

� The abstract resulted in quite a few data. I would suggest making it more informative adding the number of patients for each group and the statistically significant data about the predictors.

� Which therapy as DAPT was indicated? Aspirin and Clopidogrel in all patients? And the length of the therapy was previously established according to some risk score, bleeding risk of the patients or the complexity of the PCI?

Please specify.

� “DAPT non-adherence was defined as cessation of antiplatelet medication without any side effects or physician order.” What in case of side effect such as thrombosis? How do you consider these patients?

� The Target Lesion Revascularization is not considered. Can you explain the reason for this choice?

� The last sentence of the Statistical analysis paragraph misses the final period.

� Please add the statistical value in the Results for the predictors.

� Please specify the abbreviations of the statistical value of the Table 4 in its caption (e.g. B, S.E.)

� You showed only the predictors with statistically significant value, but you discussed the predictors of the PARIS and EDUCATED trial. What about the impact of the predictors of these trials in your population? Please, it could be relevant if you have the chance to produce the statistical analysis of these predictors and discuss them.

Thank you very much for your attention and for your interesting work.

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Reviewer #1: Yes: Alessandro Sticchi, MD.

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Incidence, Predictors, and Outcomes of DAPT Non-compliance in Planned vs. Ad Hoc PCI in Chronic Coronary Syndrome

PONE-D-21-12701R1

Dear Dr. Malik,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

R. Jay Widmer

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Dear Authors,

thank you for your sincere responses.

The clarifications and modifications you applied to the manuscript improved it despite the intrinsic and mainly acknowledged limitations.

Best regards

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Alessandro Sticchi