PONE-D-21-05156

Interfacial polarization of in vivo rat sciatic nerve with crush injury studied via broadband dielectric spectroscopy

PLOS ONE

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PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Partly

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The submission from Rita Otagiri et al. reports that the strength of injured nerve interfacial polarization was smaller than that observed in nerves without an injury. Moreover, authors suggest that BDS could be used as a tool to understand the electrical aspect of the pathophysiology of nerve injury. The study is interesting and well structured. However, there are some corrections.

Minor comments:

1. The authors should add some more current references about sciatic nerve with crush injury (doi: 10.3390/ijms21103509; doi: 10.1186/s12974-018-1303-5)

2. The authors should include in the materials and methods section the experimental groups they analyzed during the experiment.

3. The authors should better check the manuscript for any typographical errors.

Reviewer #2: This study investigated the mechanism underlining the interfacial polarization of in vivo rat sciatic nerve with crush injury. The rational behind the experiment was clear and straight forward. The manuscript is almost well written.

There are some minor grammar issues that should be fixed in order to aid the accessibility of the results to

the reader.

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Reviewer #1: No

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PONE-D-21-05156.docx

Interfacial polarization of in vivo rat sciatic nerve with crush injury studied via broadband dielectric spectroscopy

PONE-D-21-05156R1

Dear Dr. 

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Rosanna Di Paola, MD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: