Peer Review History
| Original SubmissionDecember 1, 2020 |
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PONE-D-20-37215 Program Sustainability Post PEPFAR Direct Service Support in the Western Cape, South Africa PLOS ONE Dear Dr. Chiliza- Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. I have carefully reviewed the manuscript and the reviewer comments, and please provide a major revision, taking the comments into account, and and resubmit your manuscript for reconsideration. Please note all reviewers felt this is an important and timely topic. Please take the reviewer comments into account and set out your responses to us in detail. Please note that this is not a guarantee of publication. Revisions will be sent through a secondary review process before a final decision is made. Please submit your revised manuscript by 5 March 2021. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols We look forward to receiving your revised manuscript. Kind regards, Melissa Sharer Academic Editor PLOS ONE Journal Requirements: When submitting your revision, we need you to address these additional requirements. 1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and 2. Please include additional information regarding the survey or questionnaire used in the study and ensure that you have provided sufficient details that others could replicate the analyses. For instance, if you developed a questionnaire as part of this study and it is not under a copyright more restrictive than CC-BY, please include a copy, in both the original language and English, as Supporting Information, or include a citation if it has been published previously. 3. In the Methods, please discuss whether and how the questionnaire was validated and/or pre-tested. If these did not occur, please provide the rationale for not doing so. 4. Please ensure that you refer to Figure 1 in your text as, if accepted, production will need this reference to link the reader to the figure. 5. We note you have included a table to which you do not refer in the text of your manuscript. Please ensure that you refer to Table 1 in your text; if accepted, production will need this reference to link the reader to the Table. Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Yes Reviewer #2: Partly ********** 2. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #2: N/A ********** 3. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes Reviewer #2: Yes ********** 4. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: Yes ********** 5. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: The manuscript is well written and the data and findings are presented in a clear fashion. My primary concerns with the submission is the time period in which the data is drawn. While the comparison RIC data is for the period immediately after transition, the data is five years old. There have been significant changes in the PEPFAR program since the time in which the study is conducted. At a minimum the authors should be using more recent data. Also, RIC is but one indicator which could and should be used to assess sustainability. Was there consideration given to other clinical indicators associated with the cascade, particularly HST data and viral load/suppression data? Reviewer #2: PLOS-One_Review Program Sustainability Post PEPFAR Direct Service Support in the Western Cape, South Africa December 2020 This article provides a timely and important inquiry into the sustainability of donor-supported global health programs. This is an important topic that should have far greater attention paid to it in the global health literature. There are several aspects of the paper that require further development, including more extensive engagement with the global health literature, greater attention to the context of the Western Cape province, and relative to their proposed structure of program development, consideration of the role that community-based HIV/AIDS activists have played in South African HIV/AIDS politics and policy across the institutional levels of the state. Thus, while the paper provides an interesting perspective on an important topic, it requires major revision before it can be considered for publication. As such, my recommendation for this paper is for it be revised and resubmitted for review. First and foremost, there is insufficient engagement with influential approaches to program design in the field of global health. While these approaches have been primarily framed around patient-centered health outcomes rather than sustainability, since the authors focus on retention in care (RIC) as the mechanism through which sustainability is defined, the analysis is focused on similar parameters. With respect to approaches that the authors should review and engage with, Partners in Health (PiH) have advocated for an accompaniment approach to program development that involves extended engagement with across governmental sectors, civil society, and communities. In addition, Health Alliance International (HAI) has advocated for ‘diagonal’ approaches to global donor funding that involve coordination and engagement with local governmental and civil society actors and organizations to increase the impact of donor aid on communities and produce sustainable interventions. These are but two of many approaches to sustainability for global health programs that the authors would do well to consider as part of their analysis. The analysis is also quite shallow relative to the history of global/international health, which is a bit troubling. In short, the authors are not contextualizing their findings relative to important developments/histories in the field, which limits the impact and significance of their findings. In addition, there is very little attention paid to the contextualization of this case study. I find the research to be valuable, but there is very little attention to precisely how and why the Western Cape stands out relative to other regions in South Africa relative to HIV/AIDS treatment. I have commented on this at length below and will refer the authors to my input there, but this point also links to their recommendations for program design, particularly their focus on facility managers. Taking individual leadership as a key factor without contextualizing the conditions within which facility managers operate diminishes the potential contribution. My own experience with facility managers in the Western Cape was that those who work closely with the community and HIV/AIDS activists also found success, but these sort of ties and shared governance did not find their place in the analysis or the program design recommendations the authors provide. Regarding the parameters for the analysis, I appreciate that the authors have made the decision to publish their quantitative data separately. However, to exclude the financial data on sustainability from this paper entirely is quite limiting. This sort of data would provide the necessary context for understanding why some clinics were able to undertake the transition better than others, which remains unclear in the paper. It would also strengthen the comparative value of the paper, as we don’t know the size of Pepfar programs relative to public health budgets in the Western Cape, which would seem critical to contextualizing why the province was able to absorb former Pepfar-funded NGO staff members into the public health system. It may be the case that other societies that are Pepfar recipients would be able to undertake similar measures, but we don’t have the necessary information to undertake these sort of comparative exercises. While it is likely beyond the scope of this paper, I would encourage the authors to think more critically about the broader power dynamics within which their research is situated. In thinking about “transitions” away from global donor funding, it is not only Pepfar that is noteworthy, but also the Global Fund. In short, this is a very important topic that they are engaging with, the implications of which are very much a life and death matter for many around the world, even more so as the COVID-19 pandemic brings with it economic contraction. Since many recipient countries remain caught in a situation where conditionalities associated with debt repayment mean that they cannot increase health spending without commensurate increases in GDP, the looming crisis of “transitions” in global health funding mean that many societies will be facing declining levels of donor support along with shrinking health budgets. While a drug-resistant HIV epidemic is one possible entailment of this, generalized increases in mortality, under-nutrition, and suffering are also likely. All of which is to say, I know that I have been quite critical with my review, but I have done so because I see the potential impact of this line of research and would like for the paper to reach its full potential. As such, please take my comments and critique in the constructive spirit in which they have been given, as I believe that this is an important topic that needs far greater attention. Comments Line 62 Retention in Care (RIC) – define acronym with first use Line 105 – 108 It is true that many countries began to augment transnational donor funding during this time, but it is also important to note that the 2008 financial crisis produced a levelling-off in donor funding, and that with access to HIV/AIDS treatment and small decreases in HIV incidence, that the number of PLHIV continued to increase during this time, necessitating that recipient governments augment their HIV/AIDS programs. Line 108-109 It would also be important to note that the World Bank recategorized country income levels according to new criteria during this time, which led to restrictions on donor flows, such as with the delineation of middle-income countries (MICs). That these criteria are based on aggregate income levels and do not take into account levels of social inequality has been an important critique of this process. Line 140 A bit more background on why the donor community defines sustainability along financial lines is a very important issue to contextualize. From the roots of early international health programs led by the Pan-American Health Organization (PAHO), which were funded by the Rockefeller Foundation, to the rise of selective primary healthcare and cost-recovery amid structural adjustment in the 1980s, there is a clear thread whereby donors and countries that are able to exert authority within international institutions express power by defining program sustainability and impact according to criteria that they set, one of which is financial sustainability. Line 150 – 152 Please see James Pfeiffer’s research on Mozambique on how Pepfar-funded interventions interact with public health systems, as it is more complex than these programs “working inside” public health clinics, day hospitals, etc. Line 163-164 This is a good point, but it is also important to note that the emphasis on access to treatment was also based on the logic of treatment as prevention (TasP), or that people on HIV/AIDS treatment with undetectable viral loads could not transmit the virus to other people. Line 169 On the lack of formal analysis of the transition in Pepfar programmatic leadership: who was to funded this? Who should have dedicated staff to examine this? There is an implicit critique here but it is left undefined, leading the reader to assume that the South African government should have done so. Is this the authors’ position? If so, please define. Line 174 A bit more context here on why the Western Cape was distinct is important. The concentration of tertiary services and expertise is significant, but that is informed by the uneven historical development of health services around white, urban populations that began during the colonial era, continued during apartheid, and has not been resolved during the post-apartheid era. Also, HIV/AIDS programs were developed earlier in the province under the guidance of Fareed Abdullah and his team, particularly with PMTCT, which national government intervened to stop during the dark days of the Mbeki era. But support from the Global Fund in the province, which came earlier than the rest of the country, set up the Western Cape as an early success story and a province that has continued to exhibit stronger relative program management than others. Also, I believe that a similar process had already been undertaken with a Global Fund grant in the late 2000s, so there would have been institutional knowledge on how to manage the transition of donor programs from the government to an NGO. Line 194 I hope that the financial aspects of the transition are not left out entirely, as that would weaken the robustness of the analysis considerably. Line 200 In terms of defining RIC, a bit more would be helpful. I’m assuming that you are referring to people living with HIV/AIDS (PLHIV) who were adhering to treatment that were lost to follow up (LTFU)/did not adhere after the transition on Pepfar programs? Clarifying this would be helpful. Line 216 Define primary healthcare (PHC) for first use Line 232 Of what level were the staff nurses? Clinic Nurse Practitioners would be the assumption, but please define that for the reader. Line 253 Please define modified grounded theory Line 274 Defining the donor as an NGO is confusing here, since Pepfar is a donor program funded by the US gov’t. If you are referring to a primary recipient organization (PRO) that is working with secondary recipient organization (SRO), then that needs to be defined. Also, Pepfar, the Global Fund, and several other major global health programs are public-private partnerships (PPPs), so thinking through how you define these relationships is important, as simply labeling the donor and NGO limits the applicability and impact of your findings. Also, is the grantee always local government? This section needs to be thought through much more. Line 277 Were there any parameters for defining what the coordinating position would be enabled to do/oversee? This seems a bit general and undefined since it is the key point in the section. Line 280 Donor funded organization? Seems like there is a missing word here Line 286 - 288 This is an important point that you are making, but it is not sufficiently contextualized. What you are observing is that the responsibility for a successful transition in skill transfer is decentralized and falls to the level of a facility manager. It would lead one to assume that the better capacitated facilities would therefore be better suited to have successful transfers. Since the areas with highest HIV prevalence and greatest need for skills transfer (the peri-urban townships) also tend to have over-burdened heal facilities, this is a critical point that should be further contextualized. Line 303 Define NIMART for the reader Line 314 – 31 Again, this had already been done by the WCDoH previously, with the transition of clinic management for the HIV/TB clinics established by Médecins sans Frontières (MSF) in Khayelitsha. There were some bumps in the road with these transitions, and it was a learning process. So, again, the success here is not surprising but the result of previous experience in navigating precisely this sort of transition. Line 331 Again, the fact that the extra labor associated with ensuring a sustainable transition is being transferred to the facility level is really an important point. It is not being managed by the donor, provincial health, or city health, but by the facility manager. There would be a huge range of outcomes to be expected then, which would depend not only on the personal attributes of the facility manager, but the extent to which the facility is fully staffed, operational, etc. so that the manager has the ability to focus on the transition. Also, I would assume that CNPs would play a critical role in facilitating this transition, as they often have the clearest understanding of staffing needs, shortages, and areas where increased efficiencies can be achieved. Their labor, however, is often rendered invisible in this process, which is problematic. Line 352 Define IMCI Line 391 It is helpful that you are addressing the contextual factors here, but this is insufficient to frame your findings, which are quite particular to the Western Cape. Line 396 It would be helpful to mention the role of HIV/AIDS activism in producing this change, as this was critical to enabling the shifts you identify Line 400 There is a long-standing debate on the limits of vertical, disease-specific interventions and their lack of sustainability. Proponents of using “vertical” interventions to strengthen the broader health system (horizontal) interventions have advocated for doing precisely what you advise here, to create “diagonal” programs that use vertical funding streams for health systems strengthening. Health Alliance International (HAI) has done work that has modeled this approach in Mozambique is one of the most significant examples of the potential impact and success of this approach in the global health. In general, I would recommend linking your case study and discussion of findings to the global health literature, as your case study is constructed as a stand-alone example, when in reality it is part of a broader conversation on how best to channel donor funding to improve health outcomes. Line 411 Is it because facilities are smaller or that they may be struggling to meet the level of need in communities with high burdens of disease? Line 422 Does it make sense to mention the 90-90-90 goals for the first time in the conclusion? If this is the aim of the paper, then it would make sense to introduce this goal (which we are projected to miss significantly by the way) earlier in the paper. Line 437 Who are national stakeholders? Does they include civil society and PLHIV or HIV/AIDS activists? Also, shouldn’t provincial government work with facilities and communities to understand local needs? Line 452 What are local champions? Who defines needs? What is the role of the community in this process? Line 461 It might be useful to include the provincial treasury in the key stakeholders meetings, since presumably they will need to plan several years in advance if a transition will create greater budgetary demands for the health sector. The medium term expenditure framework (MTEF) requires such advance planning for budgetary processes. Line 465 I would include the community or some proxy thereof in the final box in this section. The role of HIV/AIDS activists as counsellors and mentors who were also consulted by the WCDoH early on in the development of HIV/AIDS programs was vital to their success. Line 471 Who is funding the staffing/capacity required to develop the transition plan? Is this being done by external consultants? Line 472 The recommendation to have the skills transfer managed at the provincial level is contradicted by your evidence, which showed that facility managers oversaw this process. Line 474 Given that the entire focus of your paper is to emphasize the importance and lack of research on how care is affected by a donor transition, I am very surprised that there is not a post-transition phase for research or monitoring/evaluation. Your proposed flow of program transition would therefore reproduce the precise issue that your paper aims to rectify. ********** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #2: Yes: Theodore Powers [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.
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| Revision 1 |
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PONE-D-20-37215R1 Program Sustainability Post PEPFAR Direct Service Support in the Western Cape, South Africa PLOS ONE Dear Jessica Chiliza, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel your submission has been strengthened and requires minor revision. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. We appreciate your efforts to deepen our community's understanding of the process of sustainability as it aligns with external/PEPFAR funding in the context of South Africa. Please submit your revised manuscript by 21 April 2021. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. We look forward to receiving your revised manuscript. Kind regards, Melissa Sharer Academic Editor PLOS ONE Journal Requirements: Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice. Additional Editor Comments (if provided): Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #1: (No Response) Reviewer #2: All comments have been addressed ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: No Reviewer #2: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: N/A Reviewer #2: N/A ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes Reviewer #2: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: N/A Reviewer #2: The authors have significantly strengthened the paper through revision, and my recommendation is that the article be accepted for publication pending minor revisions, which are detailed below. Line 75 This study suggests Line 101 In 2008, or following 2008? Line 111 Missing word after “increased” Line 119 PEPFAR misspelled. Also, “after PEPFAR withdrawal” or “after the withdrawal of PEPFAR funding” Line 122 Insert “and reductions in” prior to “tracing systems” Line 171 It looks like there is an incomplete sentence here with “The donor community capacity” Paragraph starting on Line 197 This is an excellent addition to the argument. Section starting on Line 203 This is very helpful for situating the particularity of the Western Cape. Paragraph starting on Line 253 It might be useful to signal that the 90-90-90 rhetoric emanating from the UN has coincided with the leveling off of donor funding and the “transition” processes initiated by PEPFAR and the Global Fund. In short, while we have the tools to “end HIV/AIDS”, funding that would have otherwise supported this approach has been withdrawn, which has undermined this program. Perhaps this would fit best in the conclusion, but it would be worth mentioning, as this critical dynamic seems to be lost on many. Line 350 Consider rewording to: “understand the context, and local policy, and have…” Line 351 Consider rewording to: “to the context, which builds trust and results in more” Line 356 Consider rewording to: “and at a decentralized level.” Line 450 Consider rewording to: “centralized level: either the provincial or district level.” Line 455 Consider rewording to: “important for government and the NGO to be” Line 467 This interview excerpt has already been used (Line 419). Please delete one of these so that there is not repetition. Line 491 Consider rewording to: “the main concern is that if the public-sector workforce and infrastructure are undermined” Line 511 Start new paragraph with: “Donors” Line 546 Consider rewording to: “need to be intentionally” Line 554 Under “Grantee”: “Ideally have an Establish a donor coordination” Line 577 Perhaps consider including a wider array of inputs on the transition planning process. Certainly, while the donors will appreciate the objectivity of an external consultant, this is a critical moment in ensuring the long-term sustainability of the program, and there should therefore be a clear and thorough consultation process that involves the full range of stakeholders. ********** |
| Revision 2 |
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Program Sustainability Post PEPFAR Direct Service Support in the Western Cape, South Africa PONE-D-20-37215R2 Dear Dr. Chiliza, We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements. Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication. An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org. If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. Kind regards, Melissa Sharer, PhD MPH MSW Academic Editor PLOS ONE Additional Editor Comments (optional): Reviewers' comments: |
| Formally Accepted |
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PONE-D-20-37215R2 Program Sustainability Post PEPFAR Direct Service Support in the Western Cape, South Africa Dear Dr. Chiliza: I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org. If we can help with anything else, please email us at plosone@plos.org. Thank you for submitting your work to PLOS ONE and supporting open access. Kind regards, PLOS ONE Editorial Office Staff on behalf of Dr. Melissa Sharer Academic Editor PLOS ONE |
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