PONE-D-20-21489

Differences between 3D isovoxel fat suppression VIBE MRI and CT models of proximal femur osseous anatomy: A preliminary study for bone tumor resection planning

PLOS ONE

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P0008805

Korea Institute for Advancement of Technology

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The use of 3D printing in orthopedic surgery is an evolving but exciting area. Compared with conventional 2D MRI, isovoxel-3D-MRI could provide a higher resolution image without stair-step artifacts. If the osseous anatomy extracted from 3D-MRI is comparable to that of 3D-CT, 3D-MRI would have the potential to substitute 3D-CT when planning the guidance for tumor resection, thereby avoiding the radiation hazard issues of CT. This study evaluated the 3D osseous anatomy of the proximal femur extracted from 3D-MRI VIBE sequences, and measured the overall differences using CT as the reference standard. The results demonstrated that the difference between 3D-MR and CT models were acceptable with a maximal difference below 3.5mm. The WE and Dixon fat suppression methods were equivalent according to Bland–Altman plots.

This study is quite interesting to read and the conclusion is quite strong due to its experiments. Here, I have several suggestions for the authors.

1. Abbreviations, such as VIBE, should be explained at the first time it appears in your article. You can put it in your title, but for both abstract and you manuscript, you should give the full text.

2. But Dixon and WE based fat suppression techniques are not based on the saturation of the fat. It is not proper to call them fat saturation techniques.

3. Figures are quite low quality for the authors to see clearly. For example, the figure 2, the text in sub-figures can not be seen clearly at all.

4. The authors should give explanation for why fat suppression is necessary for the recon of the bone. Also the 3D osseous anatomy of the proximal femur extracted without fat suppression should be given as a baseline for comparison.

5. Dixon based fat suppression are totally different from the WE in principle. So, it is quite interesting to figure out why they are equal in the discussion, from the medical physics view. It is expected that the authors would give more evidences, such as other reports.

6. References 14 and 15, seems some typos of the authors' name.

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Reviewer #1: No

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Differences between 3D isovoxel fat suppression VIBE MRI and CT models of proximal femur osseous anatomy: A preliminary study for bone tumor resection planning

PONE-D-20-21489R1

Dear Dr. Chung,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

JJ Cray Jr., Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Most of the issues were well addressed. However, there is one problem that the authors mentioned that the Dixon and WE are equivalent, but would be saying as no significant difference would be more accurate.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No