PONE-D-20-33764

Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study

PLOS ONE

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Prof. Raffaele Serra, M.D., Ph.D

Academic Editor

PLOS ONE

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Additional Editor Comments:

The reviewers have commented on your above paper. They have suggested that this manuscript be revised according to the reviewers suggestions and resubmitted.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: No

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5. Review Comments to the Author

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Reviewer #1: The authors describe the clinical and laboratory characteristics of COVID-19 patients in high altitude areas of Sichuan province, China. According to the results present in this manuscript, the authors do not compare the patients in high and low altitude areas and only described a cohort study. Without the information of patients positive to COVID-19 in-plane area, it is difficult to correlate the symptoms and attribute some aspects with the geographic area. The results are clear and will be contributed to the knowledge of COVID-19 disease.

The manuscript must be reviewed at the grammatical and typographical levels (example: a lack of spaces between the words)

Although some aspects of these results must be improved, I recommend that this manuscript be revised.

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Reviewer #1: No

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Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study

PONE-D-20-33764R1

Dear Dr. Zhang,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Prof. Raffaele Serra, M.D., Ph.D

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

amended manuscript is acceptable

Reviewers' comments: