PONE-D-20-31507

Sulfonylureas may be useful for glycemic management in patients with diabetes and liver cirrhosis

PLOS ONE

Dear Dr. Chih-Cheng Hsu,

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Academic Editor

PLOS ONE

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: No

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: I Don't Know

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Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Authors reported SU use in patients with T2DM and compensated cirrhosis was associated with lower risks of all-cause mortality and major cardiovascular events. There are no major revisions required. Minor revisions required are as follows:

#1: Full spelling is required only for the first appearance of the abbreviation. Please correct the 113th, 123th, 129th, 131st, 132nd, 133rd, 137th, 192nd, 193rd, 226th, 232nd, 247th, 272nd, and 273rd line.

#2: Page 17, line 3: the correct one is ‘‘HCC’’, not ‘‘Hepatocellular’’.

Reviewer #2: #1 The authors defined decompensated liver cirrhosis as LC with variceal bleeding, ascites, encephalopathy, or jaundice. Under this definition, patients with compensated LC includes wide ranges of liver function. The information of liver function such as Child-Pugh score or ALBI grade is necessary.

#2 Patients with liver cirrhosis has a risk of hypoglycemia due to dysfunction in gluconeogenesis and shortage of glycogen. The authors concluded that the usage of SUs was not associated with sever hypoglycemia. The authors should mention the risk of the hypoglycemia due to LC itself in the Discusion.

#3 Space may be necessary in line 89 Page 6 (between in and 2000), line 182 Page 11 (between 7915 and patients).

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Reviewer #1: Yes: Hidehiro Kamezaki

Reviewer #2: No

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Sulfonylureas may be useful for glycemic management in patients with diabetes and liver cirrhosis

PONE-D-20-31507R1

Dear Dr. Chih-Cheng Hsu,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Tatsuo Kanda, M.D., Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: I Don't Know

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: Thank you for submitting the revise. I think there are no more major revisions required in the manuscript.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Hidehiro Kamezaki

Reviewer #2: No