PONE-D-20-23912

Effects of unipartite posterior missing-teeth on the temporomandibular joint and the alignment of cervical atlas

PLOS ONE

Dear Dr. CHIU,

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Essam Al-Moraissi

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Title

The term “Unipartite” used to describe unilateral missing molars undoes not appear in the literature (trending)  and confuses the reader. As well it may accurately indicate a missing tooth but not whether there was missing posterior support unilaterally or not.

Could you please see my attached review, I have added all my comments to the Author in an attachment.

Reviewer #2: Good study. It would have been better to take CBCT rather than panoramic and lateral cephalogram for the study subjects. Which would give much better angulation and metrics. Also in some cases the ambulation might also change due already underlying inflammatory changes.

Reviewer #3: In this paper, the authors studied the correlation between unipartite missing teeth and morphologic changes of the spine and posture. Angulations of articular eminence, cranio-cervical angle, and the percentage of the occlusal plane passing through the first and second cervical vertebrae with other morphologic geometric data were measured. It is novel and of clinical interest.

It is novel and has clinical significance.

It is known that head posture is highly correlated with craniofacial changes. On the other hand, head posture also affects the above-mentioned angle measurement. In fact, the standard procedures of radiography are sufficient for clinical diagnosis. However, in this study, it is uncertain whether measurement errors (including the reproducibility of the subject's head posture) will affect the results. In particular, it is recommended to verify the measurement error of the current scheme while maintaining sufficient reproducibility of the posture.

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Reviewer #1: Yes: Dr. Curtis Westersund

Reviewer #2: No

Reviewer #3: No

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Attachments

Attachment

Submitted filename: Reviewer Comments for PONE-D-20-23912.pdf

Effects of unilateral posterior missing-teeth on the temporomandibular joint and the alignment of cervical atlas

PONE-D-20-23912R1

Dear Dr. CHIU,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Essam Al-Moraissi

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

Reviewer #3: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I found 2 errors in formatting:

"Pdontoideum Plane" is likely meant to read Odontoideum Plane in the first paragraph on page 6

Not sure what this means at the bottom of page 9 - "joint11" but I think they have a misplace reference.

Reviewer #2: Article is good for publishing. It's a nice research and an original. The study attempts the readers to a very specific approach for diagnosis of Internal derangement

Reviewer #3: The authors did minor revision on the manuscript such as usage of terms, grammatical error etc. The manuscript is nice in the current form for publication.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Curtis Westersund

Reviewer #2: No

Reviewer #3: No