PONE-D-20-05093

Increased risk of developing dental diseases in patients with primary Sjögren’s syndrome– a secondary cohort analysis of population-based claims data

PLOS ONE

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Academic Editor

PLOS ONE

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https://doi.org/10.1007/s10067-019-04705-z

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Partly

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: N/A

Reviewer #2: No

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: As the aim of your study is to objectify side effects of pSS on oral health, you need to describe more precisely the salivary role : -buffer power

-physical obstacle

-hydration, lubrication

-Monitoring of oral microbiota,

-Tank of ions and minérals salts,

-Healing with EGF and VEGF.

You also need to emphasize on the prevention's problematic as it's difficult to provide a good oral restauration with removable denture when there is a lack of saliva.

By the end, as clinical expression of xerostomia should be different between two patients who suffer of pSS, there is a missing data, you need to objective the clinical severity of dry mouth.

Reviewer #2: Chuang et al are addressing dental disease in the context of Sjögren’s syndrome.

Major comment: No correction for multiple comparisons has been performed.

Minor comments: As the authors address risk factor of dental disease, they may address specifically the effect of treatment for Sjögren’s syndrome (e.g. did MTX-treated patients had more stomatitis? Does treatment affect the risk at all?). They may further address the effect of disease duration, since diagnosis and the one of extraglandular disease on the risk for dental disease.

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Reviewer #1: No

Reviewer #2: No

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Increased risk of developing dental diseases in patients with primary Sjögren’s syndrome– a secondary cohort analysis of population-based claims data

PONE-D-20-05093R1

Dear Dr. Koo,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Frédéric Denis, Ph.D.

Academic Editor

PLOS ONE

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Reviewers' comments: