PONE-D-20-18434

Kidney function on admission predicts in-hospital mortality in COVID-19

PLOS ONE

Dear Dr. Seyahi,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

The introduction section is not easy to read. Available evidence should be more clearly summarized and the rationale should be more clearly stated. The manuscript needs an extensive English revision. 

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Chiara Lazzeri

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: No

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5. Review Comments to the Author

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Reviewer #1: Although this reviewer warmly welcomes this manuscript, some issues should be addressed:

-The rationale for the study is unclear as the introduction is a bit confusing, comprising several pieces of apparently unlinked information. A more integrated appraisal of the relevant literature would be appropriate to provide the context for the study.

-Figures were not available.

-The following reports should be mentioned:

J Clin Med. 2020 Jun 3;9(6):E1718; doi: 10.3390/jcm9061718; PMID: 32503180.

J Clin Med. 2020;9(5):1529. doi: 10.3390/jcm9051529. PMID: 32438617.

-Values of systolic and diastolic blood pressure should be included in the analysis.

-The key role of endothelial dysfunction in the pathophysiology of kidney injury in COVID-19 (J Clin Med. 2020 May 11;9(5):1417; doi: 10.3390/jcm9051417; PMID: 32403217) should be better discussed.

-English language (syntax, grammar, correct choice of words, correct use of adjectives and adverbs) should be substantially improved throughout the text. Professional assistance should be sought.

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Reviewer #1: No

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Kidney function on admission predicts in-hospital mortality in COVID-19

PONE-D-20-18434R1

Dear Dr. Seyahi,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Chiara Lazzeri

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: