PONE-D-20-12977

ACD: Antimicrobial chemotherapeutics database

PLOS ONE

Dear Dr. Khan,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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We look forward to receiving your revised manuscript.

Kind regards,

Timir Tripathi, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments:

The database is important and the work is good but the manuscript is too short. Both reviewer feel that the manuscript may be expanded for the benefit of readers.

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" I have read the journal's policy and the authors of this manuscript have the following competing interests: [Asad U khan is editor of Plos One]"

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: N/A

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Manuscript Title: ACD: Antimicrobial chemotherapeutics database

Manuscript Number: PONE-D-20-12977

The ACD database is required as it clubs the properties of many important and significant databases from the prospect of antibacterial resistance.

The manuscript may be accepted with minor changes.

1.Slight syntax errors like ….”time to react ”…. there should be no space after react.; second line of second paragraph, font is different (antibiotic resistance); full form of ECDC should be given;

2. …..and very few are synthetic….This line in the abstract may be rewritten with better sentence format.

3.There should be the same format for heading. Most of them are in Capital sentences while a few are in Capital Word like Data Collection. There should be a uniformity in the entire manuscript.

4.As per 2014 WHO report…….updated data of MDR-TB should be provided. Data of 2014 is quite old for a database.

5.Tha abstract may be re-written as it is showing high similarity with the author's web page (amdr.amu.ac.in).

6.Introduction may be elaborated with more emphasis on the need of this database.

7.Comparison of available databases may be discussed in more detail. Further, compare this database with other available databases. Although the ACD database provides more information than current databases, a detail is required on the syntax of the database. Tools used to create ACD may be discussed with other databases and compare the limits and advantages of this database with other similar databases.

8.Its an excellent database so its appication and competativeness of the server should also be highlighted.

Reviewer #2: In the present database, "ACD: Antimicrobial chemotherapeutics database" author have collected huge informatios about antimicrobial compounds, and compiled it in this database. I my view it will be very useful for researcher working in the field of antimicrobial drug resistance. I have tried this database with two compounds and found positive results. I recommend this dataset for publication in PLOS ONE after two minor suggestions (If possible)

1.Add an option of search compound based on .SDF file of compound (if possible)

2.Add an option to search based on the peptide sequence (if possible)

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6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Dr. Asimul Islam

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PONE-D-20-12977_PloseONE.docx

ACD: Antimicrobial chemotherapeutics database

PONE-D-20-12977R1

Dear Dr. Khan,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Timir Tripathi, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Both the reviewers are satisfied with the revisions made and suggested the acceptance of the manuscript.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: N/A

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: All the queries are answered and all the suggestions are incorporated in the revised manuscript. It may be accepted for publication in the present form.

Reviewer #2: Revised MS may be accepted for publication on PLOS ONE as it is important for the researcher working in the field of drug resistance.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Dr. Asimul Islam

Reviewer #2: No