PONE-D-20-07659

The perceived impact of isoniazid resistance on outcome of first-line rifampicin-throughout regimens is largely due to missed rifampicin resistance

PLOS ONE

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Minor Revision

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: Comments to the authors

The study by Armand Van Deun et al. studied a cohort of 7291 patients from Bangladesh for the prediction of various tuberculosis resistance, mainly the involvement of initial isoniazid resistance, rifampicin-resistant, as well as multi-drug resistance in the success of various treatment regimens. The authors mentioned the success of throughout rifampicin resistance in the treatment of isoniazid-resistant TB as well as a failure of this regimen in the treatment of missed rifampicin and acquired rifampicin-resistant TB cases. Importantly, the authors mentioned that failure of other regimens, including throughout rifampicin treatment in the initially missed cases of rifampicin-resistant or acquired resistance to rifampicin, is mainly due to the detection limit in the determination of rifampicin resistance. It is evidenced from the published literature that Rifampicin resistance is commonly used as a predictor of multi-drug resistance in M. tb, also confirmed by the analysis of this study. The study is well conducted; data is well organized and presented. The manuscript is well written and understandable except the abstract that can be written in a more straightforward way to be useful for the wider audience

Abstract:

The abstract written is quite complicated. It is hard to understand. Authors are requested to write an abstract that can easily be understood.

Reviewer #2: Comments:

Overall the manuscript is broadly written about the treatment categories related to active TB. Data proved the treatment utility and recommendations in present scenario for TB programme successfully progresses worldwide. Following are some suggestions which can make the manuscript stronger and beneficial for the readers:

Abstract:

• Abbreviation of rifampicin resistance (Rr) should come upon first appearance in the text.

• Conclusive statement should be modified to give good interpretation to the reader.

Introduction:

• Abbreviation must require for rifampicin (RMP) upon first appearance in the text (Line no 60).

Method: It observed that author/s ware collected the data very precisely. However, required some information to improve manuscript like:

• Author should point out the type (pulmonary or extra-pulmonary) of tuberculosis among patient requited for this study as well as house hold contact, how developed active TB.

• In patient history, alcoholism and smoker status of patient as well as house hold contact should be noted if possible. Because these habits are strongly associated with TB disease and attributed to high risk of TB infection which leads to active TB or recurrence.

Results:

• Authors should provide the data of TB-HIV co-infected patients. Because, they may have negative in sputum smear microscopy and required initial TB treatment.

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Reviewer #1: Yes: Mohd Shariq

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PONE-D-20-07659.edited.docx

The perceived impact of isoniazid resistance on outcome of first-line rifampicin-throughout regimens is largely due to missed rifampicin resistance

PONE-D-20-07659R1

Dear Dr. Deun, 

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

HASNAIN SEYED EHTESHAM

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

In this manuscript the Authors studied a cohort of patients from Bangladesh for the prediction of various tuberculosis resistance. The reviewers made important suggestions and had questions which the authors have addressed satisfactorily. Abstract of the manuscript has been revised extensively to make it easily understandable. The inability to provide the data on TB-HIV co-infected patients is accepted. I recommend publication of this manuscript.

Reviewers' comments: