PONE-D-19-33061

In-Vitro MPI-Guided IVOCT Catheter Tracking in Real Time for Motion Artifact Compensation

PLOS ONE

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

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Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

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Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The manuscript "In-Vitro MPI-Guided IVOCT Catheter Tracking in Real Time for Motion Artifact Compensation" describes a combination of IntraVascular Optical Coherence Tomography with Magnetic Particle Imaging. The authors use MPI for determining the position as well as the velocity of the catheter during OCT. The use of a magnetic lacquer enables MPI to detect the marked areas of the catheter as has been previously shown in literature. This approach allows a radiation-free bimodal application of significant (pre-)clinical relevance. Today's standard uses as reference DSA (X-ray) imaging methods.

The manuscript is well written and understandable, the figures are comprehensive. Nevertheless, there are a few issues that need to be resolved prior to a possible publication:

l22: Please choose: "proximally rotated catheters" or "rotated proximal catherters" depending on what your want to express.

l74: You are claiming the lacquer does not affect the OCT beam profile. Please either give a suitable reference or show your measurements supporting this claim.

l92: then -> than

l97: Either "contains" or "consists of" but not "contains of".

l136: What is your criterium for declaring a value an "outlier"?

l137: What kind of smoothing did you apply?

l184: While mathematically correct, please avoid speaking of "decreased" in this context, rather use "set". A decrease leading to a higher absolute velocity if counter-intuitive for the reader.

fig4+6: I recommend to combine these two figures only displaying the contents of 4b and 6a. A constant velocity (4a) needs no depiction and I do not see the benefit of having the velocities graphically presented in 6b.

l210: You are stating that the tracked positions are in good agreement with expected values from 18mm to 10mm. Looking at the error bars of your measured values I would rather cut this argument short at 11mm.

fig7 (caption): Here you state the good agreement was from 18mm down to 6mm. This is (a) in contradiction to your own statement in the text (18mm-10mm) and also please consider my previous comment.

l215: The values of AE and RE given here do not agree with the ones given in tab1. Please verify!

l218: You are addressing "a small deviation" of the measured values from the expected ones. Looking at fig7b the measurements seems not to capture the first change in velocity at all since it starts at a wrong slope. Please discuss this result in more detail! Are there issues with higher velocities?

l227 and fig8: Similarly to the above case the velocity seems to be underestimated while you are constating a good accordance. Please comment on the too small slopes for higher velocities.

l236/7: Three times the units (mm) are missing.

l239/40 and tab3: The values given for AE/RE do not agree between table and text.

Good job!

Your Reviewer

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Reviewer #1: No

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In-Vitro MPI-Guided IVOCT Catheter Tracking in Real Time for Motion Artifact Compensation

PONE-D-19-33061R1

Dear Dr. Griese,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Wolfgang Rudolf Bauer, M.D., Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: All my remarks to the original manuscript have been fully addressed. From my side there are no more issues to be resolved prior to a possible publication.

Your reviewer.

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Reviewer #1: Yes: Volker C. Behr