PONE-D-19-28894

Extravasation and fluid collection on computed tomography imaging in patients with colonic diverticular bleeding

PLOS ONE

Dear Dr. Takada,

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Yan Li

Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: In the manuscript entitled ‘Extravasation and fluid collection on computed tomography imaging in patients with colonic diverticular bleeding’, the authors carried out a retrospective study to identify factors associated with identification of colonic diverticular bleeding. They found that extravasation and fluid collection on CT imaging were extracted as factors of identification of colonic diverticular bleeding by colonic endoscopy. Although this study seems well designed and the results are relevant to clinical practice, some issue should be properly addressed.

Comments to authors

Major comments

1. Although authors stated that endoscopy within 24 hours was important in identifying colonic diverticular bleeding, early endoscopy may have been performed in patients suspected of aggressive active bleeding. Therefore, this result may be largely related to bias. The reviewer thinks that the analysis should be based only on background findings such as CT findings as shown in the title.

2. The authors stated that extravasation and fluid collection on CT imaging were extracted as factors of identification of colonic diverticular bleeding by colonic endoscopy. The authors should refer to the characteristics of patients that had bleeding findings in the absence of such findings.

Minor comments

1. The case of diverticular bleeding is stated as 20% in the result, but 21% in the discussion.

2. The similar sentences are repeated in introduction and discussion section. Please organize these sentences.

Reviewer #2: Thank you for the invitation, in this interesting paper, authors described ‘Extravasation and fluid collection on computed tomography imaging in patients with colonic diverticular bleeding’, the paper is sound and has potential for the future clinical application, however, the authors still need to revise it before the final acceptance.

Comments to authors

1. writing skills, please don't cop and paste some sentences, please rewrite,

2. Please list patients characteristics so that the others could better understand the whole story.

3. diverticular bleeding is stated as 20%, but why showed 21% in the discussion part.

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Reviewer #1: No

Reviewer #2: No

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PONE-D-19-28894R1

Extravasation and fluid collection on computed tomography imaging in patients with colonic diverticular bleeding

PLOS ONE

Dear Dr. Takada,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

We would appreciate receiving your revised manuscript by Mar 22 2020 11:59PM. When you are ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter.

To enhance the reproducibility of your results, we recommend that if applicable you deposit your laboratory protocols in protocols.io, where a protocol can be assigned its own identifier (DOI) such that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). This letter should be uploaded as separate file and labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. This file should be uploaded as separate file and labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. This file should be uploaded as separate file and labeled 'Manuscript'.

Please note while forming your response, if your article is accepted, you may have the opportunity to make the peer review history publicly available. The record will include editor decision letters (with reviews) and your responses to reviewer comments. If eligible, we will contact you to opt in or out.

We look forward to receiving your revised manuscript.

Kind regards,

Yan Li

Academic Editor

PLOS ONE

Additional Editor Comments (if provided):

Please include a point-to-point rebuttal letter when submitting the revision, also include in the submission system

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Reviewers' comments:

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files to be viewed.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email us at figures@plos.org. Please note that Supporting Information files do not need this step.

Extravasation and fluid collection on computed tomography imaging in patients with colonic diverticular bleeding

PONE-D-19-28894R2

Dear Dr. Takada,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Yan Li

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: