PONE-D-19-26644

The efficacy of the fixed combination of latanoprost and timolol versus other fixed combinations for primary open-angle glaucoma and ocular hypertension: a systematic review and meta-analysis

PLOS ONE

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PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #2: Yes

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Reviewer #1: This is a well-done study in which the authors obtained interesting results, even if some of them were already known. This metaanalysis outlined the efficacy of fixed combination.

There are some English tense to correct, but the manuscript is well written.

Reviewer #2: Line 83. There are more fixed combination (brinzolamide/timolol, brimonidine/brinzolamide and the oldest pilocarpine/timolol). Why did you forget all these?

Line 384. Please change DTFC according with other abbreviations. Really, I would prefer all the abbreviations as DTFC than FCDT…

Line 442. Please avoid “To the best of our knowledge” and “first”. You can’t read all the published Literature and all the databases.

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Reviewer #1: No

Reviewer #2: No

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The efficacy of the fixed combination of latanoprost and timolol versus other fixed combinations for primary open-angle glaucoma and ocular hypertension: a systematic review and meta-analysis

PONE-D-19-26644R1

Dear Authors,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Simone Donati, M.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Dear Authors,

thank you for your revision.

The manuscript is now accepted for publication.

Best regards

Reviewers' comments: