PONE-D-19-30486

The Socioeconomic Impact of Orthopaedic Trauma: A Systematic Review and Meta-Analysis

PLOS ONE

Dear Mr. O'Hara,

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Osama Farouk

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: General comments:

The study idea about the socioeconomic impact of orthopaedic trauma is interesting and valuable, furthermore to be studied in a systematic review and meta- analysis study design elaborates more information in a wider and fruitful way.

In general, it’s a well written manuscript according to the PRISMA guidelines. I have provided some remarks below.

Abstract:

- The abstract is informative but the number of the included studies is not mentioned, please add it.

Methods:

Under: Data Synthesis and Analysis section, in line 122: linguistic correction; “ fractures types” to be corrected to fractures’ types or types of fractures.

Results:

All tables and figures are presented in a clear and informative way, with few comments:

- Table (1): in study types: please clarify in details the other types and insert it in the table or as a footnote under the table.

- One of the study characteristics included is fracture location of the study, in some studies more than one location were found. This characteristic is better to be included under patient characteristics as patient wise, to be included in table (2) after mechanism of injury.

- In table (3) about Socioeconomic Outcome Measures, under data collection methods: clarify in details the details in the table or as a footnote.

- The term “days absent from work” could be replaced by absenteeism days from work all over the manuscript.

Discussion:

- Is well written and covering all items.

- In line 309: What’s meant by prohibited? Please, replace with suitable term.

Reviewer #2: The Manuscript The Socioeconomic Impact of Orthopaedic Trauma: A Systematic Review and Meta-

Analysis addresses an extremely important issue of orthopedic health care: although due to aging societies, age related diseases are more and more frequent, orthopedic Trauma is jeopardizing patients in their best years. By that the quantitative description of work loss etc. is for outstanding interest for the scientific Society and I strongly recommend to publish this study. My only Question would be an Annotation in the discussion: the follow up periods are significantly different between prospective and retrospective studies, which somehow reflects a currently taking place paradigma Change in the operative disciplines a Little bit away from the prospective studies towards the large retrospective Register studies. Hence, it would be good to add one or two sentetnce in the discussion, that the Long term follow ups in orthopedic surgery require probably more big Register studies in the future. Beside this, tha manuscript has my full support for publication and I want to congratulate the authors to their work

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Reviewer #1: Yes: Dalia G Mahran

Professor of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Reviewer #2: Yes: Peter Biberthaler, MD

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The Socioeconomic Impact of Orthopaedic Trauma: A Systematic Review and Meta-Analysis

PONE-D-19-30486R1

Dear Dr. O'Hara,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

Within one week, you will receive an e-mail containing information on the amendments required prior to publication. When all required modifications have been addressed, you will receive a formal acceptance letter and your manuscript will proceed to our production department and be scheduled for publication.

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With kind regards,

Osama Farouk

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: (No Response)

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: (No Response)

Reviewer #2: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: (No Response)

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: (No Response)

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: (No Response)

Reviewer #2: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: The paper

The Socioeconomic Impact of Orthopaedic Trauma: A Systematic Review and Meta-Analysis

is Ready to go, all remarks were adressed, congrats!

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Dalia G Mahran

Reviewer #2: Yes: Peter Biberthaler