PONE-D-19-24679

Diurnal variations of amplitude of accommodation in different age groups

PLOS ONE

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Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: No

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: INTRODUCTION

- Page 3 line 53-55: Why AA is important to diagnosis either accommodative insufficiency or the accommodative excess?

- Page 3 line 59-64: Why knowing all the limitations about subjective methods to measure the AA, you chosen the Push up.

- Page 4 line 71-72: “In clinical practice, however, it is more important to assess AA based on the time of the day or the patient’s age.” Why or how you support this affirmation, indeed, in real world few times a subject has to do a lot of accommodation.

- Page 4, lines 78-85: According to that paragraph, I think, it would be better to measure the accommodative response (lag) or the accommodative facility.

- I cannot see any cause that support to perform that study.

- why you considered that age could be an important variability factor in the daily changes of the AA?

RESULTS:

- Page 9, lines 201-207: I could not understand which increases or decreases you say.

- Figure 3: It is blur and I could not see it.

- Page 10-11: The analysis of Table 3 is not clear, you say, "Regarding detection of differences (> 1.50 D) among AA values measured in each session" i.e., within the three times that you measured the AA in each S1, S2 etc, or the differences between S1, S2 etc; this is important, because in the first case, you are showing that the test used is not reliable (high AUC for adolescent and twenties) and the changes in the AA could be because a high variability by the Push up test.

DISCUSSION

- Page 16, lines 352-360: “significant diurnal changes in AA were observed between sessions measured at two-hour intervals from 9:00 a.m. to 8:00 p.m. and the changes were greater in younger age groups” I do not agree with this conclusion, because the large variability within each session could cause that differences, but no a really change in the amplitude of accommodation.

Reviewer #2: As stated by the authors in the introduction section, pupil diameter is important in the accommodation amplitude measurement.Have pupil diameters of the participants been measured? If yes, I suggest you give us some information.

I also wondered if the results were different between male and female participants. The gender of the participants is not present in the Excel file.In general, I must say that I like the article.

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Reviewer #1: No

Reviewer #2: No

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Diurnal variations of amplitude of accommodation in different age groups

PONE-D-19-24679R1

Dear Dr. Yu,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Ireneusz Grulkowski, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: thank you for the answers. I think your answers to me and the other judge are satisfactory

I think your article contains information that will contribute to the literature

congratulations

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

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Reviewer #2: No