PONE-D-19-23464

Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: prospective follow up study

PLOS ONE

Dear Dr Gebeyehu,

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Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: No

Reviewer #2: Yes

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Reviewer #1: I Don't Know

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: This study aimed to know the associated factors about the adverse drug effects during Helicobacter pylori eradication. This report is interesting and can be helpful to the clinicians for increasing compliance of H. pylori eradication regimen. However, I think that some of the results and conclusions of this paper seem to be incorrect.

Comments

1. Authors analyzed the factors associated with self-reported ADE using binary and multiple logistic regression. The results showed that failure of eradication therapy was one of the associated factors for ADE and, based on the results, the authors argued that failure of eradication therapy is one of predictors of ADEs. The factors which can affect ADEs are what we can know before treatment, therefore, treatment failure can not be included. If authors want to know that ADEs can affect treatment failure, you should analyze the associated factors for success of H. pylori eradication including ADEs as variable.

2. It will be better to make flow chart as Figure 1 for easier understanding of study sequences.

Reviewer #2: In this interesting manuscript, the authors described a prospective follow up study"Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy"

the manuscript is sound and in the good writing, I don't have any further comments on this paper, recommend to be accepted .

Thank you for invitation,

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Reviewer #1: No

Reviewer #2: No

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Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: prospective follow up study

PONE-D-19-23464R1

Dear Dr. Gebeyehu,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Yan Li

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: