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PONE-D-19-24756

Register-based cost-effectiveness analysis of organized prostate-specific antigen screening: Evidence from a randomized controlled trial

PLOS ONE

Dear Mr. Booth,

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Christopher J.D. Wallis, MD, PhD

Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: No

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Reviewer #1: Yes

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5. Review Comments to the Author

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Reviewer #1: Booth et al. examined cost-effectiveness in terms of overall mortality and prostate cancer mortality among men included in the FinRSPC prostate cancer screening trial. Neither the screening or control arm was overall cost-effective. Organized screening could be considered cost-effective in terms of prostate cancer death by preventing one death per 1000 men screened.

This is a well-written manuscript with appropriate methodology and limitations listed. A few minor recommendations for improving the manuscript:

1) Why was all follow-up truncated at 17 years? The authors state that they did it, but did not provide further rationale.

2) It would be helpful to have a Table (supplementary) or two listing assumptions, costs, etc

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Reviewer #1: No

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Register-based cost-effectiveness analysis of organised prostate-specific antigen screening: Evidence from a randomised controlled trial

PONE-D-19-24756R1

Dear Dr. Booth,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Christopher J.D. Wallis, MD, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: