[EXSCINDED]

PONE-D-19-20468

A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan

PLOS ONE

Dear Dr. Hirata,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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"This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology and the Japan Agency for Medical Research and Development. We would like to thank Editage (www.editage.jp) for the English language review."

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Partly

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

Reviewer #2: No

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5. Review Comments to the Author

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Reviewer #1: Very good paper. The authors addressed the pros and cons of all alternative methods in a good and clear way.

Minor change: Line 309, page 25. UTx should be changed to Surrogacy

Reviewer #2: I read with great interest the Manuscript titled “A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan” (PONE-D-19-20468), which falls within the aim of PLOS ONE. In my honest opinion, the topic is interesting enough to attract the readers’ attention. Methodology is accurate and conclusions are supported by the data analysis. Nevertheless, authors should clarify some points and improve the discussion citing relevant and novel key articles about the topic.

Authors should consider the following recommendations:

- Manuscript should be further revised by a native English speaker to improve its readability in some points.

- Methods. I would suggest reporting how the minimum of 200 samples for each group was calculated.

- Methods. I would suggest reporting in the methods section which was the definition of “infertility” for the subjects. Moreover, was the definition of “experience of infertility” confirmed by the subsequent evaluation of the reported infertility treatment?

- Methods. I would suggest better explaining why the maximum age was 60 years, and older subjects were excluded by the Authors.

- I could not find any information regarding the informed consent of enrolled patients. Did author obtain informed consent for each patient? Conversely, this point may raise serious concern from the ethical point of view.

- I suggest discussing, at least briefly, how the condition of infertility may have a significant and detrimental impact of psychological well-being and sexuality (refer to: PMID: 27750491; PMID: 29336414; PMID: 31466493).

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Reviewer #1: Yes: randa akouri

Reviewer #2: No

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A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan

PONE-D-19-20468R1

Dear Dr. Hirata,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Simone Garzon

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

The manuscript is well written with clear methodology. It was appreciated by the Reviewers, who suggested only some minor revision completely addressed by the Authors.

Reviewers' comments: