Peer Review History

Original SubmissionAugust 1, 2019
Decision Letter - Eduardo Fonseca-Pedrero, Editor

[EXSCINDED]

PONE-D-19-21674

Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use

PLOS ONE

Dear Rasmus Trap Wolf,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

We would appreciate receiving your revised manuscript by Oct 25 2019 11:59PM. When you are ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter.

To enhance the reproducibility of your results, we recommend that if applicable you deposit your laboratory protocols in protocols.io, where a protocol can be assigned its own identifier (DOI) such that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). This letter should be uploaded as separate file and labeled 'Response to Reviewers'.
  • A marked-up copy of your manuscript that highlights changes made to the original version. This file should be uploaded as separate file and labeled 'Revised Manuscript with Track Changes'.
  • An unmarked version of your revised paper without tracked changes. This file should be uploaded as separate file and labeled 'Manuscript'.

Please note while forming your response, if your article is accepted, you may have the opportunity to make the peer review history publicly available. The record will include editor decision letters (with reviews) and your responses to reviewer comments. If eligible, we will contact you to opt in or out.

We look forward to receiving your revised manuscript.

Kind regards,

Eduardo Fonseca-Pedrero, PhD

Academic Editor

PLOS ONE

Journal Requirements:

When submitting your revision, we need you to address these additional requirements.

Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

http://www.journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and http://www.journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: No

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The paper has an important justification of the study, highlights the convenience of evaluate the potential of a new screening algorithm to identify children with sub-threshold and undiagnosed mental disorders, in a general population. A combination of historical birth cohort data and high-quality data from national registers is used.

Some interesting results and discussion are added to the international scientific literature.

It is a good paper. However, the manuscript has some weakness, which must be improved:

p.1-2. “Today more than 13% of children and adolescents worldwide are affected by mental disorders at any given time (1) with a significantly negative impact on their quality of life (2).” The date of the two previous cited papers are 2015 and 2002. Please add more recent papers. I recommend some recent publications: Self-reported mental health in children ages 6–12 years across eight European countries. Eur. Child Adolesc. Psychiatry 2018, 27, 785–795 (http://dx.doi.org/10.1007/s00787-017-1073-0) or International and Spanish Findings in Scientific Literature about Minors’ Mental Health: Predictive Factors Using the Strengths and Difficulties Questionnaire (2019)( DOI: 10.3390/ijerph16091603).

p.44-45. Please do the same with the 9 cited papers, used to explain the recent situation? Please look for more recent published papers.

p.61 “There exists several studies evaluating different screening programs (15)”. Please add more references than one.

p.77 “i.e. the children’s IQ”. Please define IQ.

p.134. Please clarify the definition of MHP . You do not make differences between borderline and abnormal? (see https://www.sdqinfo.com/) Please clarify it in the manuscript.

p447. Maybe table 9 could be deleted and insert all the information of this table in a paragraph, directly in the text.

p463. Could you think about insert other international results in the discussion, in order to compare you results with other international papers or find a possible explanation? Maybe it would improve the paper. There is no one reference in discussion and conclusions. Please consider it.

Reviewer #2: The work entitled “Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use" is of great interest. The research is very stimulating; it contains new scientific knowledge and provides comprehensive information for further development of this productive line of research. The data are presented in a clear and easy-to-understand fashion, and the paper is, principally, well-argued and clearly worthy of publication. However, I have some comments to make that should be addressed before I recommend this manuscript for publication

From my point of the view, the introduction would benefit from the inclusion of more literature about the SDQ use in mental health screening worldwide. Considering that the study is about the mental health problems and the parents’ report about mental health, some other studies about this would be advisable. For instance: Bach et al., 2019; Navarro et al., 2019; Ortuño-Sierra, Aritio-Solana, and Fonseca-Pedrero, 2018.

In the results section, it is not clear to me why the authors say that: “To investigate whether this subgroup of children with MHP have an unmet need for care, we use the children’s later school performance as an indicator of the consequences of their MHP at the age of 11-12 years”. In my opinion, this should be at least explained in the introduction. Is it there more literature confirming that a decrease in school performance can be used as an indicator of a increase in mental health problems

In the discussion section authors state that: “The 77.3% of children with MHP who do not receive any SMHC during the follow-up period also obtain a statistically significantly worse GPA at their 9th grade exams than children with no MHP.” I do not clearly understand if the comparison should be between those who have MHP and those without MHP. It is not clear if the difference is because the lack of intervention or because of the fact that they have MHP. Authors explain this, but it seems obvious, so do not really see the point of including this.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files to be viewed.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email us at figures@plos.org. Please note that Supporting Information files do not need this step.

Attachments
Attachment
Submitted filename: Review_SDQ_PlosOne_2019.docx
Revision 1

Response to Reviewers

The following text is attached in a pdf-file as well.

Dear Editor,

We have made all the changes in the manuscript needed to meet PLOS ONE's style requirements.

We would like to thank the reviewers for their constructive and valuable comments and suggestions. These inputs have helped us significantly improve the manuscript by clarifying unclear points and referencing additional relevant studies.

Below we address each reviewer’s comments separately. The changes made to the manuscript to address the reviewers’ comments is in red font (only in attached pdf).

Reviewer #1:

Comment 1:

p.1-2. “Today more than 13% of children and adolescents worldwide are affected by mental disorders at any given time (1) with a significantly negative impact on their quality of life (2).” The date of the two previous cited papers are 2015 and 2002. Please add more recent papers. I recommend some recent publications: Self-reported mental health in children ages 6–12 years across eight European countries. Eur. Child Adolesc. Psychiatry 2018, 27, 785–795 (http://dx.doi.org/10.1007/s00787-017-1073-0) or International and Spanish Findings in Scientific Literature about Minors’ Mental Health: Predictive Factors Using the Strengths and Difficulties Questionnaire (2019)( DOI: 10.3390/ijerph16091603).

Thank you for the comment. Following the comment, we have re-reviewed the literature. We still find our two references to be highly relevant. Polanczyk et al. (2015) is the largest existing meta-study on prevalence of mental disorders and is well executed methodologically. Sawyer et al. (2002) is one of the few papers that studies children’s mental health disorders and health-related quality of life in a large representative sample.

Comment 2:

p.44-45. Please do the same with the 9 cited papers, used to explain the recent situation? Please look for more recent published papers.

Following the reviewer’s suggestion, we have re-reviewed the literature, which has led us to include seven additional references in the introduction and methods section:

Line 52:

9. Copeland WE, Wolke D, Shanahan L, Costello EJ. Adult Functional Outcomes of Common Childhood Psychiatric Problems: A Prospective, Longitudinal Study. JAMA Psychiatry. 2015;72: 892. doi:10.1001/jamapsychiatry.2015.0730

Line 75:

18. Roberts RE, Fisher PW, Blake Turner J, Tang M. Estimating the burden of psychiatric disorders in adolescence: the impact of subthreshold disorders. Soc Psychiatry Psychiatr Epidemiol. 2015;50: 397–406. doi:10.1007/s00127-014-0972-3

Line 77:

19. Balázs J, Miklósi M, Keresztény Á, Hoven CW, Carli V, Wasserman C, et al. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk: Adolescent subthreshold-depression and anxiety. J Child Psychol Psychiatry. 2013;54: 670–677. doi:10.1111/jcpp.12016

Line 94:

21. Kristoffersen JHG, Obel C, Smith N. Gender differences in behavioral problems and school outcomes. J Econ Behav Organ. 2015 Jul;115:75–93.

22. Keilow M, Sievertsen HH, Niclasen J, Obel C. The Strengths and Difficulties Questionnaire and standardized academic tests: Reliability across respondent type and age. Goertz M, editor. PLOS ONE. 2019 Jul 25;14(7):e0220193.

Line 133:

32. Ortuño-Sierra J, Aritio-Solana R, Fonseca-Pedrero E. Mental health difficulties in children and adolescents: The study of the SDQ in the Spanish National Health Survey 2011–2012. Psychiatry Res. 2018 Jan;259:236–42.

Line 143:

34. Stringaris A, Goodman R. The Value of Measuring Impact Alongside Symptoms in Children and Adolescents: A Longitudinal Assessment in a Community Sample. J Abnorm Child Psychol. 2013;41: 1109–1120. doi:10.1007/s10802-013-9744-x

Comment 3:

p.61 “There exists several studies evaluating different screening programs (15)”. Please add more references than one.

Thank you for the comment. Our reference is a 2019 systematic review, it therefore covers existing studies evaluating different screening programs. To clarify, we added the following red text to the manuscript:

Line 70: As outlined in a recent review, there exists several studies evaluating different screening programs (15)

Comment 4:

p.77 “i.e. the children’s IQ”. Please define IQ.

Thank you for the suggestion. All variables are defined in the methods section. To clarify, we added the following red text to the manuscript:

Line 87-88: The methods section provides the precise definitions of the potential confounders.

Comment 5:

p.134. Please clarify the definition of MHP. You do not make differences between borderline and abnormal? (see https://www.sdqinfo.com/) Please clarify it in the manuscript.

Thank you for the suggestion. To clarify, we added the following red text to the manuscript:

Line 152-153: Thus, we do not distinguish between different levels of MHP in this study.

Comment 6:

p447. Maybe table 9 could be deleted and insert all the information of this table in a paragraph, directly in the text.

Thank you for the suggestion. We have deleted table 9 and added the following red text to the manuscript:

Line 456-461: The results include the 44 children with mental health problems and minimum one contact with SMHC. We find that the mean number of days between the parents’ completion of SDQ and their children’s first contact with SMHC was 945 days, and the median was 1,000 days. The 25% and 75% percentiles were 426 days and 1,311 days, respectively. Thus, the results show that…

Comment 7:

p463. Could you think about insert other international results in the discussion, in order to compare you results with other international papers or find a possible explanation? Maybe it would improve the paper. There is no one reference in discussion and conclusions. Please consider it.

Thank you for the comment. To address this comment, we added the following red text to the manuscript:

Line 483-483: This finding is in line with previous studies that have found an association between SDQ scores and school outcomes [21,22]. The results indicate….

Reviewer #2:

Comment 1:

From my point of the view, the introduction would benefit from the inclusion of more literature about the SDQ use in mental health screening worldwide. Considering that the study is about the mental health problems and the parents’ report about mental health, some other studies about this would be advisable. For instance: Bach et al., 2019; Navarro et al., 2019; Ortuño-Sierra, Aritio-Solana, and Fonseca-Pedrero, 2018.

Thank you for the comment. Following the comment, we have re-reviewed the literature including the suggested references. We have chosen to include those references that we believe have direct relevance to the paper.

As mentioned in the response to reviewer #1 1e have added the following the following seven references to the introduction and methods section in the manuscript:

Line 52:

9. Copeland WE, Wolke D, Shanahan L, Costello EJ. Adult Functional Outcomes of Common Childhood Psychiatric Problems: A Prospective, Longitudinal Study. JAMA Psychiatry. 2015;72: 892. doi:10.1001/jamapsychiatry.2015.0730

Line 75:

18. Roberts RE, Fisher PW, Blake Turner J, Tang M. Estimating the burden of psychiatric disorders in adolescence: the impact of subthreshold disorders. Soc Psychiatry Psychiatr Epidemiol. 2015;50: 397–406. doi:10.1007/s00127-014-0972-3

Line 77:

19. Balázs J, Miklósi M, Keresztény Á, Hoven CW, Carli V, Wasserman C, et al. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk: Adolescent subthreshold-depression and anxiety. J Child Psychol Psychiatry. 2013;54: 670–677. doi:10.1111/jcpp.12016

Line 94:

21. Kristoffersen JHG, Obel C, Smith N. Gender differences in behavioral problems and school outcomes. J Econ Behav Organ. 2015 Jul;115:75–93.

22. Keilow M, Sievertsen HH, Niclasen J, Obel C. The Strengths and Difficulties Questionnaire and standardized academic tests: Reliability across respondent type and age. Goertz M, editor. PLOS ONE. 2019 Jul 25;14(7):e0220193.

Line 133:

32. Ortuño-Sierra J, Aritio-Solana R, Fonseca-Pedrero E. Mental health difficulties in children and adolescents: The study of the SDQ in the Spanish National Health Survey 2011–2012. Psychiatry Res. 2018 Jan;259:236–42.

Line 143:

34. Stringaris A, Goodman R. The Value of Measuring Impact Alongside Symptoms in Children and Adolescents: A Longitudinal Assessment in a Community Sample. J Abnorm Child Psychol. 2013;41: 1109–1120. doi:10.1007/s10802-013-9744-x

Comment 2:

In the results section, it is not clear to me why the authors say that: “To investigate whether this subgroup of children with MHP have an unmet need for care, we use the children’s later school performance as an indicator of the consequences of their MHP at the age of 11-12 years”. In my opinion, this should be at least explained in the introduction. Is it there more literature confirming that a decrease in school performance can be used as an indicator of a increase in mental health problems

Thank you for the comment. The aim of this section of the paper was to clarify that also the children who screen positive for MHP, but do not receive mental health care, may be affected by MHP. As studies find that school performance is an important proxy for future life prospects (21–23), we use school performance as a potential indicator of consequences of MHP. To clarify that the comparison is not between the two groups of children that screen positive for MHP, but between children that screen negative for MHP and children that screen positive for MHPs and do not receive mental health care, we added the following red text to the manuscript:

Line 406-408: Thus, finding a negative association between having MHP without receiving SMHC and later school performance, compared to children with no MHP, will indicate that there is an unmet need for care.

In addition, the following text in the background section (line 91-96) explains the choice of school performance as outcome:

The children’s later school performance is investigated as a primary indicator of the long-term outcome of the screening for MHP in preadolescence. As previous studies find an association between children’s MHP and their school performance [20–22], and school performance and schooling are known to be comprehensive predictors for the rest of a child’s life with respect to both wealth, health, and happiness [23–25], this indicator is well-suited for the evaluation of the screening.

Comment 3:

In the discussion section authors state that: “The 77.3% of children with MHP who do not receive any SMHC during the follow-up period also obtain a statistically significantly worse GPA at their 9th grade exams than children with no MHP.” I do not clearly understand if the comparison should be between those who have MHP and those without MHP. It is not clear if the difference is because the lack of intervention or because of the fact that they have MHP. Authors explain this, but it seems obvious, so do not really see the point of including this.

Thank you for the comment. The reason for describing the above is to highlight that, in comparison to children with no health problems, the majority of the children with mental health problems (the 77.3% who test positive for MHP but do not receive specialized care) have worse school outcome. This result suggests that it is not only the 22.7% that at some point receive specialized mental health care, who could potentially benefit from an early intervention. This result is described in line 487-488 in the manuscript.

Attachments
Attachment
Submitted filename: Response to Reviewers.pdf
Decision Letter - Eduardo Fonseca-Pedrero, Editor

Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use

PONE-D-19-21674R1

Dear Dr. Rasmus Trap Wolf,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

Within one week, you will receive an e-mail containing information on the amendments required prior to publication. When all required modifications have been addressed, you will receive a formal acceptance letter and your manuscript will proceed to our production department and be scheduled for publication.

Shortly after the formal acceptance letter is sent, an invoice for payment will follow. To ensure an efficient production and billing process, please log into Editorial Manager at https://www.editorialmanager.com/pone/, click the "Update My Information" link at the top of the page, and update your user information. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to enable them to help maximize its impact. If they will be preparing press materials for this manuscript, you must inform our press team as soon as possible and no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

With kind regards,

Eduardo Fonseca-Pedrero, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Formally Accepted
Acceptance Letter - Eduardo Fonseca-Pedrero, Editor

PONE-D-19-21674R1

Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use.   

Dear Dr. Wolf:

I am pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please notify them about your upcoming paper at this point, to enable them to help maximize its impact. If they will be preparing press materials for this manuscript, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

For any other questions or concerns, please email plosone@plos.org.

Thank you for submitting your work to PLOS ONE.

With kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Eduardo Fonseca-Pedrero

Academic Editor

PLOS ONE

Open letter on the publication of peer review reports

PLOS recognizes the benefits of transparency in the peer review process. Therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. Reviewers remain anonymous, unless they choose to reveal their names.

We encourage other journals to join us in this initiative. We hope that our action inspires the community, including researchers, research funders, and research institutions, to recognize the benefits of published peer review reports for all parts of the research system.

Learn more at ASAPbio .