PONE-D-19-17880

Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: a systematic review and meta-analysis.

PLOS ONE

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https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf

https://academic.oup.com/jid/article/218/5/673/4956225

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MC has received honoraria as a speaker and/or advisor from  Abbott, Bayer, Cephalon, Gilead, Novartis and ViiV Healthcare, SGP  has received  research grants from Gilead Sciences, ViiV Healthcare, Abbott, MS&D, and  honoraria as a speaker from MS&D, Gilead Sciences, ViiV Healthcare, Abbvie, Janssen. These activities were not related to their work with this review

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Reviewers' comments:

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Reviewer #1: Partly

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: There are several mislabeled items in the plots. Please mention if the authors performed tests for multiplicity.

Reviewer #2: The Authors performed a systematic review and meta-analysis of RCTs comparing dolutegravir-containing ART to non-dolutegravir containing ART in HIV-infected naive patients.The manuscript is well written and represents a very comprehensive analysis on this topic. The methodology is adequate and updated.

I have just one suggestion. Since the use of patients reported outcomes represent a more useful tool compared to clinician report of adverse events and they can explore outcomes such as patients' satisfaction with treatment, and considering the high virological response rates reported in some comparison between INSTI-based regimens in particular, it could be useful to include, when available, PROs as specific outcomes in the metanalysis (Whol, The Patient - Patient-Centered Outcomes Research, 2018).

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Reviewer #1: No

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PONE-D-19-17880_Comments due 23 July 2019.docx

Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: a systematic review and meta-analysis.

PONE-D-19-17880R1

Dear Dr. Cruciani,

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With kind regards,

Giuseppe Vittorio De Socio, MD, PhD

Academic Editor

PLOS ONE

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