Fig 1.
Time course of change in Y-BOCS and Q-LES-Q-SF across subjects: The range of duration for the follow-up period varied across subjects (maximum range: 974-3203 days post initial stimulation).
Individualized trajectories of percent change in Y-BOCS and Q-LES-Q-SF were represented over the available follow-up period. Individual dotted lines denote unique subjects. The two thick lines are the linear least square regression (loess) for each metric across all subjects. LOESS data are modeled up to 72 months follow-up across subjects.
Fig 2.
Association of Y-BOCS and Q-LES-Q-SF change during DBS follow-up: Using a linear mixed model, we observed a significant association between quality of life and OCD severity, finding that for every 1-point increase in QOL (Q-LES-Q-SF), OCD symptoms (Y-BOCS) dropped by 0.15 points.
The negative relationship supports the conclusion that as Q-LES-Q-SF improves there is a concordant improvement in Y-BOCS.
Fig 3.
A. Representative Subject (7) showing the change overtime for Y-BOCS and QoL at 1 month resolution.
It shows that the QoL is more variable than the YBOCS. B. All subjects – same resolution (each circle size represents the IQR (interquartile range) for all subjects at that time point. Each dot size conveys the number of subjects which will influence IQR). This is a higher resolution plot in 30-day medians.
Fig 4.
Self-reported changes regarding quality-of-life domains post-DBS: In interviews, patients were asked about each domain in the Q-LES-Q-SF scale to understand whether quality of life stayed the same, improved, or worsened because of DBS surgery.
The figure depicts patients’ responses to the interview questions, including two new categories of “fluctuated” and “complicated,” to include patients who felt that their experience did not fall under “improved,” “stayed the same,” or “worsened.”.
Fig 5.
Visualization of qualitative coding process for pre-DBS themes: Select patient quotes from interview transcripts were used to illustrate the qualitative coding process.
The figure does not include all pre-DBS themes or every patient quote associated with each theme.
Table 1.
Participant quotes indicating improvements in functioning.
Table 2.
Participant quotes regarding housing and living environments.
Fig 6.
Self-reported ratings of improvement and disappointment in quality-of-life post-DBS: The figure displays patient responses to the interview questions: “Where would you rank the level of improvement in the quality of your life since receiving DBS surgery on a scale of 0-10, where 0 is not improvement in quality of life and 10 is the tremendous improvement in quality of life?” and “Out of all the domains on the Q-LES-Q-SF, were there any that stayed the same? If yes, are you disappointed that things haven’t changed? Where would you rank that level of disappointment on a scale of 0-10, where 0 is not disappointed at all and 10 is the most disappointed you’ve ever felt?”.
Table 3.
Summarized participant responses on timeframe and longevity of DBS impact.
Table 4.
Participant quotes regarding big picture improvement.