Fig 1.
(A) Dynamic light scattering (DLS), (B) Zeta potential, (C) X-ray diffraction (XRD), (D) Atomic force microscopy (AFM), and (E) Transmission electron microscopy (TEM) of silver nanoparticles gel.
Fig 2.
(A) Dynamic light scattering (DLS), (B) Zeta potential, (C) X-ray diffraction (XRD), (D) Atomic force microscopy (AFM), and (E) Transmission electron microscopy (TEM) of gold nanoparticles gel.
Table 1.
Effect of silver, gold, and their mixed nanogel formulations on excision wound model (%wound contraction) in female albino rats on 1st, 4th, 7th, 14th, and 21st days.
Fig 3.
Photographs of the wound healing effect of different treatment groups at different daily intervals (1st, 4th, 7th, 14th, and 21st days).
Fig 4.
Showing the effect of different nanogel formulations on inflammatory mediators (NO and MPO, respectively) on the 21st day.
Values were expressed as mean ±SD(n = 6), In the same column, the same superscript letters indicated non-significant difference and different superscript letters indicated the significant difference between the different groups. ANOVA test followed by turkey’s multiple comparison test between groups at P < 0.05 were applied.
Fig 5.
Showing the effect of different nanogel formulations on the angiogenic factor (VEGF) on the 21st day.
Values were expressed as mean ±SD(n = 6), In the same column, the same superscript letters indicated non-significant difference and different superscript letters indicated the significant difference between the different groups. ANOVA test followed by turkey’s multiple comparison test between groups at P < 0.05 were applied.
Fig 6.
Showing the effect of different nanogel formulations on granulation tissue contents (hydroxyproline and hexosamine, respectively) the 21st day.
Fig 7.
Showing the effect of different nanogel formulations on histological alterations on the 21stday.
Fig 8.
Showing the effect of different nanogel formulations on collagen formation using MT stain on the 21stday.
Table 2.
Showing patch Dock results of Au, Ag nanoparticles, or their mixture on protease enzymes (collagenase, elastase, and trypsinase).
Table 3.
Showing Autodock results of Au, Ag nanoparticles, or their mixture on protease enzymes (collagenase, elastase, and trypsinase).
Fig 9.
Showing the molecular docking of metal ions (Au, Ag and their mixture) with protease enzymes (collagenase, elastase and trypsinase).
Table 4.
Showing the forecasting ADMET properties of Au, Ag, or their mixture.