Table 1.
Inclusion and exclusion criteria.
Fig 1.
PROFIL-1—SPIRIT Schedule of enrolment, interventions, and assessments.
The schedule summarizes participant enrolment, baseline assessments, study interventions, imaging procedures, and follow-up visits at 3, 6, and 12 months. QoL questionnaires (EORTC QLQ-C30 and EQ-5D-5L) are administered at baseline and follow-up time points. An optional post-induction LAFOV PET/CT (t2) may be performed after the fourth cycle of chemo-immunotherapy.
Fig 2.
NSCLC: Non-small cell lung cancer: AGAs: Actionable genomic alterations; LAFOV 18F-FDG PET/CT: Long axial field of view 18F-fluorodeoxyglucose positron emission tomography-computed tomography.
Fig 3.
Example for an acquisition protocol for a dynamic acquisition over one bed position followed by Patlak reconstructions with IDIF and PBIF based procedures with the Biograph Vision QuadraTM.