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Table 1.

Participating Institutions.

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Table 2.

Eligibility criteria for the study.

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Fig 1.

Treatment protocols planned for the study.

Arrows indicate administration time points within each treatment arm. GEM, gemcitabine; GS, gemcitabine and S-1; GS-RT, gemcitabine and S-1 with concurrent radiotherapy.

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Fig 2.

Participant timeline.

This figure summarizes participant timeline throughout the study period, including enrollment, neoadjuvant gemcitabine and S-1 (GS or GS-RT) treatment, preoperative evaluation, surgery, and postoperative follow-up.GS, gemcitabine and S-1; GS-RT, gemcitabine and S-1 with concurrent radiotherapy.

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