Table 1.
Directory of Commonly Used Antimicrobial Agents in Our Hospital.
Fig 1.
Flow diagram of the study design and sample selection.
Data source: Hospital Prospective Prescription Review System (V6.0); study design: Pre-post intervention. Included: Outpatient antimicrobial prescriptions; excluded: Anti-tuberculosis, anti-parasitic, and anti-viral drugs. Sampling method: Systematic random sampling. Pre-intervention period: July 1–December 31, 2024 (n = 12,132); Post-intervention period: January 1–June 30, 2025 (n = 11,982). Core processes: Refined rule formulation → PPR system configuration → Irrational prescription rate analysis.
Table 2.
Alert Levels in the Prescription Pre-review System.
Fig 2.
Flow diagram of prescription processing in the prospective prescription review system.
Physicians prescribe → PPR system conducts real-time review, processed by alert levels: Level 1 (Acceptable): Record and release; level 3 (Use with caution): Pop-up reminder; level 5 (Not recommended): Intercept for pharmacist review; level 8 (Contraindicated): Mandatory block, resubmit after modification.
Table 3.
Differences Between New and Old Rules.
Table 4.
Comparison of Types of irrational Antimicrobial Prescriptions.
Fig 3.
Comparison of inappropriate outpatient antimicrobial prescription rates across different categories before and after intervention.
X-axis: Categories of irrational prescriptions (indication, special populations, drug-drug interaction, dosage/route, administration frequency/solvent); Y-axis: irrational prescription rate (%). Rates of control group (N = 12,132) vs. intervention group (N = 11,982): 2.65%/0.67%, 1.36%/1.21%, 3.68%/3.03%, 8.14%/2.09%, 4.63%/0.79%.