Fig 1.
Flow chart of the present study.
Table 1.
The patients’ and healthy controls’ demographic and treatment information.
Fig 2.
The areas of greater volume reduction in the treatment-resistant schizophrenia (TRS) group compared to the non-TRS group with the significant threshold as uncorrected p < 0.05.
Left panels: the lateral (upper) and medial (lower) surfaces of the left hemisphere. Right panels: the lateral (upper) and medial (lower) surfaces of the right hemisphere.
Fig 3.
The areas with a reduction of the regional volume ratio in the TRS and non-TRS groups at the whole brain level revealed by the ANCOVA for the TRS, non-TRS, and HC groups with the significance threshold as p < 0.05 with FDR correction.
(A) The areas with a greater reduced volume ratio in the TRS group compared to the HCs. (B) The areas with a greater reduced volume ratios in the non-TRS group compared to the HCs. These figures line up from left to right with the lateral and medial surfaces of the left hemisphere and the medical and lateral surfaces of the right hemisphere of the brain.
Table 2.
Cortical areas that may be relevant to the CLZ response (with uncorrected p < 0.05).
Fig 4.
The brain areas related to responsiveness to clozapine.
The different colors indicate whether the significant areas are related to ΔGAF (blue), CGI-C (green) or both (red). Left panels: the lateral (upper) and medial (lower) surfaces of the left hemisphere. Right panels: the lateral (upper) and medial (lower) surfaces of the right hemisphere.