Fig 1.
Comparison of macrophages morphology in bone marrow.
(a) A representative image of non-activated macrophages and non-hemophagocytes. (b) A representative image of activated macrophages and non-hemophagocytes. (c) A representative image of activated macrophages and hemophagocytes. Arrowheads show phagocytized red blood cells, Scale bar = 10 μm.
Table 1.
Patients’ demographic and clinical characteristics at the time of bone marrow aspiration.
Table 2.
Laboratory findings at the time of bone marrow aspiration.
Table 3.
Correlation between serum presepsin levels and other biomarkers including bone marrow aspiration findings.
Fig 2.
Correlation between serum presepsin levels and bone marrow aspiration findings.
(a) Correlation with number of macrophages. (b) Correlation with number of hemophagocytes. The scores are calculated using Pearson’s product-moment correlation coefficients. p < 0.05, 100 LPF: 100 fields of view at low power fields.
Fig 3.
Comparison of macrophage marker and presepsin precursor protein expression in the lymph node and bone marrow.
IHC is performed using CD68 (PG-M1) and CD14 (D7A2T) antibodies. The panels (a-c) show negative staining and (d-f) show positive staining for hemophagocytosis in the lymph node. Similarly, the panels (g-i) show negative staining and (j-l) show positive staining for hemophagocytosis in the bone marrow. Arrowheads show phagocytic cells. Scale bar = 50 μm.