Fig 1.
The MAD between correlation matrices of replicate data and simulated data in the simulation scenarios.
Boxplots illustrating the MAD between correlation matrices of 100 replicate posterior predictive data sets and the simulated data set at each time point. Results are shown for three simulation scenarios with different levels of dependency between five metabolites: (a) scenario 1 (positive dependencies), (b) scenario 2 (no dependencies), and (c) scenario 3 (mixture of negative and positive dependencies).
Fig 2.
The MAD values between correlation matrices of replicate data from the fitted model and plasma metabolites data.
Boxplots of the MAD values between correlation matrices of 100 posterior predictive replicate data sets from the multivariate and independent models and observed plasma metabolites data of the A-Diet Confirm study at different time points.
Fig 3.
Number of flagged individuals for metabolite pairs.
A heat map illustrating the number of flagged individuals in which the pair of metabolites (in the corresponding row and column) contributes to flagging the individuals within a time point.
Fig 4.
Radar plot of plasma metabolite levels for a non-flagged individual.
A radar plot showing the plasma metabolite levels of a typical, non-flagged individual from the A-Diet Confirm study at time points. The shaded regions denote the 97.5% HPD intervals of the individual’s posterior predictive distribution, while the light grey lines illustrate the metabolite levels of the entire study cohort.
Fig 5.
Radar plot of plasma metabolite levels with intra-individual variation.
A radar plot illustrating the plasma metabolite levels of an individual from the A-Diet Confirm study at time points. The shaded regions denote the 97.5% HPD intervals of the individual’s posterior predictive distribution and light grey lines signify the metabolite levels of the entire study cohort. Intra-individual variation is visible in six metabolites (indicated by bold font and *) at the third time point as the individual‘s observed metabolite levels exceed their 97.5% HPD intervals.