Table 1.
Clinicodemographic patient characteristics (n = 93).
Fig 1.
Flow diagram of patient enrollment, exclusions, and follow-up across study time points (T0–T2).
T0 indicates transfer to the rehabilitation department after completion of acute stroke care; T1, 2 weeks after comprehensive rehabilitation; and T2, 3 months after stroke onset.
Table 2.
Serial trends in serum biomarker levels in the total population and BDNF genotype groups.
Fig 2.
Serial levels of serum biomarkers in total patients.
**p < 0.01, ***p < 0.001 between each time point after Bonferroni correction. Serial changes in serum concentrations of (A) mature BDNF, (B) proBDNF, and (C) MMP-9. Abbreviations: BDNF, brain-derived neurotrophic factor; MMP-9, matrix metalloproteinase-9; T0, completion of acute stroke care; T1, 2 weeks after transfer to the rehabilitation department; T2, 3 months post-stroke onset.
Fig 3.
Serial functional status in total patients.
*p < 0.05, **p < 0.01, ***p < 0.001 between each time point after Bonferroni correction. Serial changes in (A) stroke severity (NIHSS score), (B) cognitive function (MMSE score), (C) motor function (FMA score), (D) balance (BBS score), and depressive mood (GDS-SF score). Abbreviation: NIHSS, National Institutes of Health stroke scale; BBS, Berg Balance Scale; FMA, Fugl-Meyer Assessment; K-MMSE, Korean Mini-Mental State Examination; GDS-SF, Geriatric Depression Scale-Short Form; T0, completion of acute stroke care; T1, 2 weeks after transfer to rehabilitation department; T2, 3 months post-stroke onset.
Table 3.
Multiple linear regression analysis of potential baseline (T0) parameters prognostic of functional status at the early subacute phase of stroke (T1).
Table 4.
Multiple linear regression analysis of potential baseline parameters (T0) prognostic of functional status at the late subacute phase of stroke (T2).