Table 1.
Clinical characteristics of the study population according to timing of therapeutic hypothermia initiation (≤6 h vs > 6–12 h).
Table 2.
Association of clinical and biochemical variables with the composite outcome of death or brain injury on MRI.
Fig 1.
Distribution of onset of therapeutic hypothermia by timing group and HIE severity.
Boxplot showing the distribution of the onset of therapeutic hypothermia (hours) across timing categories (≤6 h vs. > 6– ≤ 12 h), stratified by hypoxic–ischemic encephalopathy (HIE) severity. Individual points represent each neonate.
Table 3.
Crude and adjusted odds ratios for the association between the timing of therapeutic hypothermia initiation and the composite outcome of death or brain injury on MRI.
Table 4.
Crude and adjusted odds ratios for the association between timing of therapeutic hypothermia and brain MRI-confirmed neurological injury.