Fig 1.
Flowchart of participants through the study.
Table 1.
Baseline characteristics of participants.
Table 2.
FAR values based on time windows.
Fig 2.
Bar chart of FAR values based on time windows.
Table 3.
Risk factors for SA-AKI patients by univariate logistic analysis.
Table 4.
Multivariate logistic regression analysis of risk factors in SA-AKI patients.
Table 5.
Multivariate Cox regression analysis of risk factors in SA-AKI patients.
Table 6.
Multivariate logistic regression analysis of risk factors for SA-AKI in patients without COPD and hypertension.
Table 7.
Multivariate Cox regression analysis of risk factors for SA-AKI in patients without COPD and hypertension.
Fig 3.
Subgroup analyses of the association between FAR and SA-AKI.
Each stratification adjusted for the factors (gender, race, age, COPD, hypertension, diabetes, heart failure, Vasopressor use, MV, DIC, SOFA score, SAPSII score, Creatinine, PT, APTT, Platelets, WBC and MBP) except the stratification factor itself. COPD = chronic obstructive pulmonary disease, MV = mechanical ventilation, DIC = disseminated intravascular coagulation, SOFA = sepsis-related organ failure assessment, SAPSII = simplified acute physiology score II, PT = prothombin time, APTT = activated partial thromboplastin time, WBC = white blood cell count, MBP = mean blood pressure.
Fig 4.
RCS curve fitting of relationship between FAR with SA-AKI.
The solid line and dashed line represented the estimated values and their corresponding 95% confidence intervals. Only 95% of the data were displayed. Adjusted for all factors (age, gender, race, COPD, hypertension, diabetes, heart failure,Vasopressor use, MV, DIC, SOFA score, SAPSII score, Creatinine, PT, APTT, Platelets, WBC and MBP).
Table 8.
Comparison of prognostic FAR and other clinical markers.
Fig 5.
The ROCs for FAR, SOFA, and FAR combined with SOFA in predicting the incidence of SA-AKI.
ROC: receiver operating characteristic curve, AUC: area under the curve, FAR: the ratio of fibrinogen to albumin, SOFA: sepsis-related organ failure assessment, SA-AKI: sepsis-associated acute kidney injury.