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Fig 1.

SPIRIT schedule of enrolment, intervention and assessment.

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Fig 2.

Flowchart of the study design.

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Table 1.

Dose recommendations of local anaesthetics.

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Table 1 Expand

Fig 3.

Timeline of the study procedure, showing which data will be collected at what time point.

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Table 2.

Potential (S)AEs related to the use of local anaesthetics.

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Table 2 Expand