Table 1.
Sample characteristics.
Table 2.
Treatment course.
Table 3.
Hospital course.
Table 4.
Individual case details.
Table 5.
Cohort average pressures during SCPP protocol. (Average values are shown for SCPP days 1-5, as only 6 of 18 patients underwent SCPP monitoring for >5 days; full data beyond SCPP day 5 are available upon request).
Fig 1.
Standard box-and-whisker plots depicting summary statistics for daily recorded values of MAP, ITP, and SCPP.
Individual measurements are shown as dots. Thick lines depict median values, boxes depict interquartile ranges (IQR), and whiskers depict lowest and highest data points within 1.5 times the IQR. (Data are shown for SCPP days 1-5, as only 3 patients underwent SCPP monitoring for >5 days; full data beyond SCPP day 5 are available upon request). MAP: mean arterial pressure; ITP: intrathecal pressure; SCPP: spinal cord perfusion pressure.
Fig 2.
Hourly pressures during SCPP protocol for A: Patient 2, who sustained a T3 AIS A SCI after a fall, and B: Patient 8, who sustained a C6 AIS D SCI with central cord syndrome after a fall.
MAP: mean arterial pressure; ITP: intrathecal pressure; SCPP: spinal cord perfusion pressure.
Fig 3.
Sankey diagram AIS grades at presentation, 72 hours post-injury, and at discharge for the cohorts, including AIS conversions between time-points.
The width of each band is proportional to the number of patients represented at each point. AIS: American Spinal Injury Association Impairment Scale.
Fig 4.
A decision-tree displaying our general approach to the pragmatic SCPP protocol, indicating when to consider MAP augmentation vs. CSFD to bring SCPP to the goal range.
LD: lumbar drain; ITP: intrathecal pressure; SCPP: spinal cord perfusion pressure; CSFD: cerebrospinal fluid diversion.