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Fig 1.

SPIRIT study protocol schedule of enrolment, interventions, and assessments.

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Table 1.

Example of a supervised exercise session. Note that all exercise prescription is based on individual preferences, abilities, medical considerations and goals.

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Table 2.

Example exercise plan.

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Table 2 Expand

Table 3.

Description, measurement variables, methods of assessment, and aggregation for secondary outcomes.

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Table 3 Expand