Table 1.
Basic characteristics of PPIs in FAERS.
Fig 1.
PPI adverse reaction reports(2004-2024).
The x-axis shows the reporting year, and the y-axis displays the number of reports on a log10 scale (1, 10, 100, 1k, 10k), illustrating the yearly volume of adverse event submissions related to proton pump inhibitors.
Fig 2.
Relationship between the number of adverse reaction reports related to PPIs and the duration of medication.
The x-axis lists individual PPIs, and the stacked bars represent the proportion of reports falling into different time-to-onset intervals (0–30 days, 31–90 days, 91–180 days, 181–360 days, > 360 days), allowing visual comparison of onset-time patterns across drugs.
Table 2.
The top 20 adverse reactions of six PPIs at the Preferred Term (PT) level.
Fig 3.
Heatmap of the adverse reactions of six types of PPIs classified according to the System Organ Class (SOC).
The y-axis lists SOC categories, and the x-axis lists PPIs. Color intensity corresponds to the log10-transformed number of reports (per the legend scale), providing an overview of reporting distribution across organ systems.