Table 1.
Demographics and characteristics. HDGECs = Huntington´s disease gene-expansion carriers, N = Number of participants, SD = standard deviation, UHDRS-TMS = Unified Huntington´s Disease Rating Scale – Total Motor Score, Q-Alb = cerebrospinal fluid/plasma albumin quotient, IQR = interquartile range.
Fig 1.
Distribution, box plot and individual data points of cerebrospinal fluid/plasma albumin quotient (Q-Alb) between motor manifest Huntington´s Disease gene-expansion carriers (HDGECs), pre-motor manifest HDGECs and controls.
The boxplots display the median, the interquartile range (IQR), and the whiskers that extend to 1.5 × IQR. Group differences in Q-Alb were assessed using ANCOVA with age included as a covariate.
Table 2.
Demographic and characteristics of participants who underwent lumbar puncture twice. HDGECs = Huntington´s disease gene-expansion carriers, N = Number of participants, UHDRS-TMS = Unified Huntington´s Disease Rating Scale – Total Motor Score, SD = standard deviation, Q-Alb = cerebrospinal fluid/plasma albumin quotient, IQR = interquartile range.
Table 3.
Demographics and characteristics. HDGECs = Huntington´s disease gene-expansion carriers, N = Number of participants, SD = standard deviation, UHDRS-TMS = Unified Huntington´s Disease Rating Scale – Total Motor Score, Q-Alb = cerebrospinal fluid/plasma albumin quotient, CSF % Th17.1 cells (of leucocytes) = the prevalence of T Helper 17.1 cells out of leucocytes measured in the cerebrospinal fluid, IQR = interquartile range.
Fig 2.
The association between the prevalence of intrathecal T helper 17.1 (Th17.1) cells and log-transformed cerebrospinal fluid/plasma albumin quotient (Q-Alb) across Huntington´s Disease Gene Expansion Carriers (HDGECs).
Linear regression analysis was performed to assess the relationship between Q-Alb and the prevalence of Th17.1 cells.
Table 4.
Demographics and characteristics. HDGECs = Huntington´s disease gene-expansion carriers, N = Number of participants, SD = standard deviation, UHDRS-TMS = Unified Huntington´s Disease Rating Scale – Total Motor Score, PDGFR-β = platelet-derived growth factor receptor-β, Q-Alb = cerebrospinal fluid/plasma albumin quotient, IQR = interquartile range.
Fig 3.
Distribution, box plot and individual data points of cerebrospinal fluid platelet-derived growth factor- β (PDGFR-B) between motor manifest Huntington´s Disease gene-expansion carriers (HDGECs), pre-motor manifest HDGECs and controls.
The boxplots display the median, the interquartile range (IQR), and the whiskers that extend to 1.5 × IQR. Group differences in PDGFR-β were assessed using ANCOVA with age included as a covariate.
Fig 4.
The association between log-transformed platelet-derived growth factor β (PDGFRB) in cerebrospinal fluid and log-transformed cerebrospinal fluid/plasma albumin quotient (Q-Alb) across Huntington´s disease gene expansion carriers (HDGECs).
Linear regression analysis was performed to assess the relationship between Q-Alb and PDGFR- β.