Fig 1.
The schematic diagram of the LRRK2 protein with different functional domains [9].
Reported definitive disease-associated variants are listed below the diagram. The variants detected in this study are listed above the diagram, of which the considered likely pathogenic variants and risk variants are highlighted in red and blue, respectively. ANK, ankyrin; ARM, armadillo; COR, C-terminal of ROC; KIN, kinase; LRR, leucine-rich repeat; LRRK2, leucine rich repeat kinase 2; ROC, ras-of-complex.
Table 1.
Minor allele frequencies and potential pathogenicity of twelve detected LRRK2 missense variants.
Fig 2.
Conservation analyses of partial LRRK2 protein regions.
The arrows indicate the amino acid residues at the mutated sites and those conserved in at least nine of ten species are highlighted in red. LRRK2, leucine rich repeat kinase 2.
Table 2.
Allelic and genotypic distributions of twelve detected LRRK2 missense variants in Han Chinese patients with PD and controls.