Fig 1.
Image (1) and sketch (2) of the time-place maze that was used in the experiment.
The maze apparatus includes: start box (length: 65 cm; width:60 cm; height: 60 cm), bridge 1 (longer arm: 40 cm; shorter arm: 15 cm, height: 60 cm), bridge 2 (longer arm: 90 cm; shorter arm: 55 cm, height: 60 cm), and reward box (length: 65 cm; width:60 cm; height: 60 cm). The starting point and time-door is located in the start box.
Fig 2.
Time line of the time-place maze protocol according to the sessions of each phase.
The experiment was done in three phases included training phase, screening phase, and main phase.
Fig 3.
Details of a session of the training phase in the time-place maze protocol.
Free movement was only implemented in the first session of the training phase. Training program (1st and 2nd sets of training) was implemented in all sessions of the training phase and main phase of the experiment.
Fig 4.
Algorithmic approach to correcting the failure of a rat in the training program of time-place maze protocol.
The correction type 1 was used in bridge trains failure, and the correction type 2 in bridge tests failure.
Fig 5.
Details of screening phase in the time-place maze protocol.
Fig 6.
Algorithmic approach to implementation of the main phase in the time-place maze protocol.
Table 1.
Results of the training and screening phases of the time-place maze.
Table 2.
Sequence of the randomized tests in the screening and main phases of the time-place maze.
Table 3.
Results of the training program in the main phase of the time-place maze.
Table 4.
Findings of the 100 randomized tests in the main phase of the time-place maze.
Fig 7.
Trends of successful randomized tests in ten sessions of the main phase of time-place maze for each rat with respect to the bridge 1 and 2 tests.