Fig 1.
Illustration of coupled PK model.
Table 1.
Model parameters for each drug when used individually.
Fig 2.
Amount -time curves of drug X based on the coupled PK model- gastrointestinal tract compartment.
Fig 3.
Amount -time curves of drug X based on the coupled PK model- the central compartment.
Fig 4.
Amount -time curves of drug X based on the coupled PK model- the peripheral compartment.
Fig 5.
Amount -time curves of drug X based on the coupled PK model- elimination accumulated.
Table 2.
Impact of absorption parameters based on a coupled pharmacokinetic model on various pharmacokinetic parameters.
Fig 6.
Flowchart for solving model parameters.
Table 3.
Comparison of theoretical values and numerical solutions.
Fig 7.
The fitted curve of drug amount in the central compartment over time under Gaussian noise condition with .
Table 4.
Sensitivity analysis of the PSO regularization parameter λ.
Table 5.
Results under bootstrap.
Fig 8.
and AIC under different ablation settings.
Table 6.
Information of the included studies.
Table 7.
Rate parameters and apparent volume for individual drug administration.
Fig 9.
The fitting curve of drug amount in the central compartment over time under the single-drug condition- metoprolol alone.
Fig 10.
The fitting curve of drug amount in the central compartment over time under the single-drug condition- captopril alone.
Table 8.
Interaction parameters for combined drug administration.
Fig 11.
The fitted curve of drug amount in the central compartment over time under combined-drug conditions.