Fig 1.
Biological samples collected for BRIST-IVF.
Icon made by Freepik/DinosoftLabs from www.flaticon.com. EDTA: Ethylenediaminetetraacetic acid, ACD: acid citrate dextrose, NMR: nuclear magnetic resonance. *21 plasma samples failed NMR quality control, 1 sample was not sent for analysis due to participant not undergoing ART treatment.
Fig 2.
Flowchart of study recruitment.
Table 1.
Characteristics of the women recruited to the study (N = 501)*.
Table 2.
Characteristics of the partners (N = 465).
Fig 3.
Overview of treatment cycles in IVF/ICSI.
Ovarian stimulation aims to stimulate follicles to produce multiple mature oocytes to be retrieved via follicular aspiration. Mature oocytes are fertilised in vitro via IVF or ICSI and successful fertilisation results in the formation of embryos. Embryos of sufficient quality can be transferred into the uterus without freezing (fresh embryo transfer) or may be frozen and stored for future use. Frozen embryos can then be thawed and transferred into the uterus (frozen embryo transfer). For each ovarian stimulation cycle, there may be both a fresh embryo transfer and multiple frozen embryo transfers. Couples/individuals may undergo multiple ovarian stimulation cycles. Icon made by Freepik/cube29/Backwoods/Smashicons from www.flaticon.com.
Fig 4.
Flowchart of the pregnancy follow up to date.
Table 3.
Planned analyses in the Bristol IVF Study.