Fig 1.
Disease carrier frequencies in each city of Anhui Province.
The diagram shows distribution of at-risk population screened by expanded carrier screening in Anhui Province.
Fig 2.
Genes for screening with different carrier frequency.
The graph indicates the number of genes with different level of carrier rates based on the large ECS screening study in Anhui Province.
Table 1.
Basic Parameters of Models and Range for Sensitivity analysis.
Table 2.
Base-case cost-effectiveness analyses summary.
Fig 3.
Cost-effectiveness acceptability curves are shown for different size of expanded carrier frequency.
The dotted lines represent the probability of each strategy being cost-effective at willingness-to-pay thresholds of US $0/payoff to US $10 000/payoff. (A) part A indicates the probability of cost-effectiveness at different willingness-to-pay thresholds with payoff 1 (the avoidance of unnecessary) in the Preconception model; (B) part B shows the cost-effectiveness acceptability analysis with payoff 2 (the number of the newborn without recessive monogenic genetic diseases) in the Preconception model; (C) part C indicates the probability of cost-effectiveness with payoff 1 in the During pregnancy model; (D) part D express the analysis between three size of ECS with payoff 2 in the During pregnancy model. All results of probabilistic sensitivity analyses for three panels were undergoing 1,000 Monte Carlo simulations.