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Table 1.

Summary of key literature on AI-based retinal disease diagnosis.

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Fig 1.

Proposed workflow of the automated retinal disease classification system.

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Fig 2.

Sample from the dataset with all classes.

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Table 2.

Complete system specifications used for model training and evaluation.

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Table 3.

Training and optimization parameters for all deep learning models.

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Table 4.

Performance comparison of different deep learning models for retinal disease classification.

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Fig 3.

Heatmap comparison of performance metrics across the four evaluated models: Scratch Model, EfficientNet-B0, EfficientNet-B7, and AlexNet.

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Fig 4.

Processing time comparison for the scratch model, EfficientNet-B0, EfficientNet-B7, and AlexNet.

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Table 5.

Five-fold cross-validation results for AlexNet.

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Fig 5.

Bar chart showing R2 scores across five cross-validation folds for the AlexNet model.

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Fig 6.

Radar chart of model metrics.

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Fig 7.

Assessment of the accuracy of proposed and compared models.

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Fig 8.

Residual values and heatmap analysis for models.

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Fig 9.

Visualization of SHAP-based interpretability analysis for three representative retinal images.

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Fig 10.

Confusion matrix of the AlexNet model showing classification performance.

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Table 6.

Model performance summary.

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Table 7.

Wilcoxon signed rank test for classification models.

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