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Table 1.

Trends in ADRD incidence across socio-demographic Index quintiles,1992−2019.

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Fig 1.

Temporal change in the numbers, proportion and ASIR of ADRD incidence across (a) sex and (b) SDI quintiles from 1990 to 2021.

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Fig 2.

World map of age-standardized incidence rate in 2021 for ADRD in 204 countries and territories.

Reprinted from Resource and Environmental Science Data Platform [https://www.resdc.cn], under a CC BY license, with permission from the Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, original copyright © 2014-2025.

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Fig 3.

World map of net drift of incidence during 1992 − 2021 for ADRD in 204 countries and territories.

Reprinted from Resource and Environmental Science Data Platform [https://www.resdc.cn], under a CC BY license, with permission from the Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, original copyright © 2014-2025.

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Fig 3 Expand

Fig 4.

Age distribution and local drifts of ADRD incidence by SDI quintiles.

(a) Temporal change in age distribution of ADRD incidence numbers from 1990 to 2021. (b) Local drifts of ADRD incidence (estimates from age-period-cohort models) for 12 age groups from 1992 to 2021. The dots and error bar indicate the annual percentage change (% per year) and the corresponding 95% CIs.

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Fig 4 Expand

Fig 5.

Long-term trends of age-specific, period-based, and cohort-based variation of ADRD incidence across (a) global and (b) SDI quintiles during 1992-2021.

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Fig 5 Expand

Fig 6.

Age, period and cohort effects on ADRD incidence by SDI quintiles.

(a) Age effects are shown by the fitted longitudinal age curves of incidence rate (per 100,000) adjusted for period deviations. (b) Period effects are shown by the relative incidence rate and computed as the ratio of age-specific rates from 1992-1996 to 2017 2021, with the reference period from 2002 to 2006. (c) Cohort effects are shown by the relative risk of incidence rate and computed as the ratio of age-specific rates from the 1897 cohort to the 1977 cohort, with the referent cohort set at 1937. The dots and error bar indicate incidence rates or rate ratios and the corresponding 95% CIs.

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Fig 6 Expand

Fig 7.

Predicted trends of ADRD incidence globally to 2036.

The (a) red and (b) blue triangles indicate the true value of ASIR from 1990 to 2021 for female and male, the dotted lines and the light color regions indicate the predicted value and the corresponding 95% CIs.

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Fig 7 Expand