Table 1.
Formula and signal detection criteria for reporting odds ratio (ROR), proportional reporting ratio (PRR) and Bayesian confidence propagation neural network (BCPNN).
Table 2.
AE-associated demographic information from FAERS.
Fig 1.
Demographic information reported by AEs in FAERS.
A A flow chart of this study; B Number of two drugs reported per year; C Number of reports by age for the two drugs; D Rates were reported by sex for the two drugs;The outer circle represents penicillamine, and the inner circle represents trientine.
Fig 2.
Number of reports by region for the two drugs.
Table 3.
Comparison of the first 30 high signal intensity adverse events (AEs) between penicillamine and trientine.
Fig 3.
Signal intersection and signal distribution characteristics.
A Positive signal intersection of three signal detection methods (ROR, PRR, BCPNN) for the two drugs. B Top 30 AE names and corresponding SOCs with the highest percentage of signals for penicillamine.See S1 Fig for Figure C.
Table 4.
Comparison of system organ classification (SOC) Distribution of adverse events between penicillamine and trientine.
Fig 4.
Network plot of the distribution of AE signals in each SOC of penicillamine.
The root node represents the drug name and the number of AE signals, the inner circle is the SOC, and the outer circle is the AE signal name.See S2 Fig for Figure trientine.
Fig 5.
Forest plot and volcano plot of ROR values (95% CI) for the first 30 high signal intensity AEs of penicillamine versus trientine.
A,penicillamine;B,trientine.Two drugs-related AE volcano plots;ROR,reporting odds ratio; P-adjust, p-value after Bonferroni correction.
Fig 6.
Wayne diagram showing the PT positive signaling network of two copper chelators in the FAERS database.
Table 5.
Time to onset of -associated adverse events and Weibull distribution analysis.
Fig 7.
A Time to onset of adverse events induced by penicillamine.
B Cumulative incidence of adverse events related to two drugs over time. See S3 Fig for Figure C.
Fig 8.
Forest plot of ROR values used to assess gender differences in penicillamine-related AEs.