Fig 1.
Schedule of enrollment, interventions, and assessments.
Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events; ESAS, Edmonton Symptom Assessment System; EQ-5D-5L, EuroQol-5 Dimension-5 Level; mMRC, Modified Medical Research Council; NRS, numeric rating scale; RC, research coordinator; RT, respiratory therapist; SPOT-ON, Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology.*Patients will be followed for 30 days after end of treatment or until death, whichever occurs first.**Patients will start SPOT-ON after 72 hours of enhanced usual care if they still meet eligibility criteria at that time. ***Vital signs will be measured every 8 hours during the trial.
Fig 2.
Abbreviation: SPOT-ON, Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology.
Table 1.
Blinding procedures in SPOT-ON randomized clinical trial.
Fig 3.
Abbreviations: NRS, Numeric Rating Scale; RT, Respiratory Therapist. Respiratory therapists will identify preferred dyspnea treatment choices with individual patients based on time-limited trials and offer personalized use of oxygen using the specified modalities over the remaining 72 ± 4 hours.
Table 2.
SPOT-ON device settings.
Table 3.
Comparison of traditional and personalized clinical trial design.