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Table 1.

Characteristics of adverse events of prostate cancer treatments in the United States.

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Fig 1.

Flow diagram.

Data are from US FDA’s Adverse Event Reporting System (FAERS) through to April 30, 2024. Group 1, Enzalutamide with other medications (excluding other ARPIs); Group 2, Apalutamide with other medications (excluding other ARPIs); Group 3, Darolutamide with other medications (excluding other ARPIs); Group 4, Abiraterone with other medications (excluding other ARPIs); Group 5, Abiraterone + Enzalutamide with other medications (excluding Apalutamide or Darolutamide). P-value, Chi-square test or Fisher’s exact test. Missing values removed.

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Table 2.

Adverse Events of prostate cancer treatments in the United States by age group.

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Table 2 Expand

Table 3.

Adverse Events of prostate cancer treatments in the United States by treatment group.

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Table 3 Expand

Fig 2.

Proportional reporting ratios and 95% confidential intervals in Group 1 to Group 5.

Data are from US FDA’s Adverse Event Reporting System (FAERS) through to April 30, 2024. Group 1, Enzalutamide with other medications (excluding other ARPIs); Group 2, Apalutamide with other medications (excluding other ARPIs); Group 3, Darolutamide with other medications (excluding other ARPIs); Group 4, Abiraterone with other medications (excluding other ARPIs); Group 5, Abiraterone + Enzalutamide with other medications (excluding Apalutamide or Darolutamide). PRR, proportional reporting ratio. Top 3 statistically high risk adverse events by group.

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Fig 2 Expand